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Age-dependent differences in cation-osmotic haemolysis in rats

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Abstract

Erythrocyte microrheology changes were measured by cation-osmotic hemolysis (COH) in rats of different age groups (3, 12 and 24 months). COH in 12-month-old rats was significantly lower in low ionic strength media (spectrin skeleton) in comparison with 3-month-old rats. This decrease was much more pronounced in 24-month-old animals, in which a significant decrease in COH in incubating media with higher ionic strength was also observed. The relationship between COH and eryhtrocyte deformability is also discussed. We suggest that changes in biophysical state of spectrin skeleton are followed by changes in lipid bilayer properties.

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Authors and Affiliations

  1. Department of Experimental Medicine, Medical Faculty of P.J. Ŝafárik University, Koŝice, Slovak Republic

    G. Mojžiŝová

  2. Department of Pharmacology, Medical Faculty, P.J. Ŝafárik University, Tr. SNP 1, 040 66, Koŝice, Slovak Republik

    J. Mojžiŝ, A. Nicák & L. Mirossay

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  1. J. Mojžiŝ
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  2. A. Nicák
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  3. G. Mojžiŝová
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  4. L. Mirossay
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Correspondence to J. Mojžiŝ.

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Mojžiŝ, J., Nicák, A., Mojžiŝová, G. et al. Age-dependent differences in cation-osmotic haemolysis in rats. Comp Haematol Int 9, 152–155 (1999). https://doi.org/10.1007/BF02600375

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