Skip to main content
Log in

Abuse potential of various opioid medications

  • Brief Reports
  • Published:
Journal of General Internal Medicine Aims and scope Submit manuscript

Abstract

The abuse potentials of various narcotic medications were assessed by surveying 130 hospital patients who admitted to having abused prescription narcotics within the preceding six months. 85% of the subjects surveyed reported having tried controlled-release narcotic preparations for abuse purposes and 60% reported that they were of little or no use. To obtain another index of abuse potential, the author asked the subjects to estimate the street prices of various medications. The street prices of controlled-release formulations were lower than those of other narcotic medications and those of some uncontrolled nonnarcotic medications. These results suggest that controlled-release narcotic formulations may have a lower potential for abuse than do other narcotic medications. In situations where there is concern about potential abuse or diversion of prescribed narcotics, controlled-release preparations may be an appropriate alternative to high-peaking, rapid-onset opioid formulations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Sigler KA, Guernsey BG, Ingrim NB, Buesing AA. Effect of triplicate prescription law on prescribing of schedule II drugs. Am J Hosp Pharm. 1985;42:857–9.

    Google Scholar 

  2. Weintraub M, Singh S, Byrne L, Maharaj K, Guttmacher L. Consequences of the 1989 New York State triplicate benzodiazepine prescription regulations. JAMA. 1991;266:2392–7.

    Article  PubMed  CAS  Google Scholar 

  3. Zullich SG, Grasela TH, Fiedler-Kelly JB, Gengo FM. Impact of triplicate prescription program on psychotropic prescribing patterns in long-term care facilities. Ann Pharmacother. 1992;26:539–46.

    PubMed  CAS  Google Scholar 

  4. Cooper JR, Czechowicz DJ, Peterson RC, Molinari SP. Prescription drug diversion control and medical practice. JAMA. 1992;268:1306–10.

    Article  PubMed  CAS  Google Scholar 

  5. Glass RM. Benzodiazepine prescription regulation: autonomy and outcome. JAMA. 1991;266:2431–3.

    Article  PubMed  CAS  Google Scholar 

  6. Stimmel B. Pain, Analgesia and Addiction: The Pharmacologic Treatment of Pain. New York: Raven Press, 1983.

    Google Scholar 

  7. Khojasteh A, Evans W, Reynolds RD. Controlled-release oral morphine sulfate in the treatment of cancer pain with pharmacokinetic correlation. J Clin Oncol. 1987;5:956–61.

    PubMed  CAS  Google Scholar 

  8. Jasinski DR. Assessment of the abuse potentiality of morphinelike drugs. In: Martin WR (ed). Handbook of Experimental Pharmacology. Heidelberg, Germany: Springer Verlag, 1977.

    Google Scholar 

  9. Roberts J. In Focus. Emerg Med News. 1992;6:3–5.

    Google Scholar 

  10. Crews JC, Denson DD. Recovery of morphine from a controlled-release preparation. Cancer. 1990;66:2642–4.

    Article  PubMed  CAS  Google Scholar 

  11. National Institute on Drug Abuse. Data from the Drug Abuse Warning System, 1977. NIDA Statistical Series; 1988. U.S. Department of Health and Human Services publication ADM 88-1854.

  12. National Household Survey on Drug Abuse: Population Estimates 1990. Rockville, MD: National Institute on Drug Abuse, 1991. U.S. Department of Health and Human Services publication ADM 91-1732.

    Google Scholar 

  13. Melzack R. The tragedy of needless pain. Sci Am. 1990;162:19–25.

    Google Scholar 

  14. Selbst SM, Clark M. Analgesic use in the emergency department. Ann Emerg Med. 1990;19:1010–3.

    Article  PubMed  CAS  Google Scholar 

  15. Marks RM, Sachar EJ. Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med. 1973;78:173–81.

    PubMed  CAS  Google Scholar 

  16. Agency for Health Care Policy and Research. Acute Pain Management: Operative or Medical Procedures and Trauma. U.S. Department of Health and Human Services, 1992. AHCPR 92-0032.

  17. American Pain Society. Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain. Skokie, IL: American Pain Society, 1992.

    Google Scholar 

  18. Brookoff D, Polomano R. Treating sickle cell pain like cancer pain. Ann Intern Med. 1992;116:364–8.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Received from the University of Tennessee College of Medicine, Memphis, Tennessee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brookoff, D. Abuse potential of various opioid medications. J Gen Intern Med 8, 688–690 (1993). https://doi.org/10.1007/BF02598290

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02598290

Key words

Navigation