Abuse potential of various opioid medications
- 111 Downloads
The abuse potentials of various narcotic medications were assessed by surveying 130 hospital patients who admitted to having abused prescription narcotics within the preceding six months. 85% of the subjects surveyed reported having tried controlled-release narcotic preparations for abuse purposes and 60% reported that they were of little or no use. To obtain another index of abuse potential, the author asked the subjects to estimate the street prices of various medications. The street prices of controlled-release formulations were lower than those of other narcotic medications and those of some uncontrolled nonnarcotic medications. These results suggest that controlled-release narcotic formulations may have a lower potential for abuse than do other narcotic medications. In situations where there is concern about potential abuse or diversion of prescribed narcotics, controlled-release preparations may be an appropriate alternative to high-peaking, rapid-onset opioid formulations.
Key wordsnarcotics opioids drug abuse prescribing controlled-release medications
Unable to display preview. Download preview PDF.
- 1.Sigler KA, Guernsey BG, Ingrim NB, Buesing AA. Effect of triplicate prescription law on prescribing of schedule II drugs. Am J Hosp Pharm. 1985;42:857–9.Google Scholar
- 6.Stimmel B. Pain, Analgesia and Addiction: The Pharmacologic Treatment of Pain. New York: Raven Press, 1983.Google Scholar
- 8.Jasinski DR. Assessment of the abuse potentiality of morphinelike drugs. In: Martin WR (ed). Handbook of Experimental Pharmacology. Heidelberg, Germany: Springer Verlag, 1977.Google Scholar
- 9.Roberts J. In Focus. Emerg Med News. 1992;6:3–5.Google Scholar
- 11.National Institute on Drug Abuse. Data from the Drug Abuse Warning System, 1977. NIDA Statistical Series; 1988. U.S. Department of Health and Human Services publication ADM 88-1854.Google Scholar
- 12.National Household Survey on Drug Abuse: Population Estimates 1990. Rockville, MD: National Institute on Drug Abuse, 1991. U.S. Department of Health and Human Services publication ADM 91-1732.Google Scholar
- 13.Melzack R. The tragedy of needless pain. Sci Am. 1990;162:19–25.Google Scholar
- 16.Agency for Health Care Policy and Research. Acute Pain Management: Operative or Medical Procedures and Trauma. U.S. Department of Health and Human Services, 1992. AHCPR 92-0032.Google Scholar
- 17.American Pain Society. Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain. Skokie, IL: American Pain Society, 1992.Google Scholar