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Investigation into the tuberculostatic activity of some aromatic hydroxy compounds

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Summary

A number of aromatic hydroxy compounds, mainly derivatives of orsellinic acid were tested in vitro againstMycobacterium tuberculosis. Some of these compounds, e.g. the 2-hydroxy-4-alkoxy-benzoic acids showed marked tuberculostatic activity. Among the esters tested are some new compounds.

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Authors and Affiliations

  1. The Research Department of N.V. Koninklijke Pharmaceutische Fabrieken v/h Brocades-Stheeman & Pharmacia Amsterdam, Amsterdam

    J. Gootjes, A. J. Zwart Voorspuij & W. Th. Nauta

  2. The University Hospital, Department for Internal Diseases, Leyden

    J. Gootjes, A. J. Zwart Voorspuij & W. Th. Nauta

  3. The Chemical Laboratory of the “Vrije Universiteit”, Amsterdam

    J. Gootjes, A. J. Zwart Voorspuij & W. Th. Nauta

Authors
  1. J. Gootjes
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  2. A. J. Zwart Voorspuij
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  3. W. Th. Nauta
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Additional information

This research was supported in part by Riker Laboratories Inc., Los Angeles, California.

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Gootjes, J., Zwart Voorspuij, A.J. & Nauta, W.T. Investigation into the tuberculostatic activity of some aromatic hydroxy compounds. Antonie van Leeuwenhoek 19, 237–244 (1953). https://doi.org/10.1007/BF02594850

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  • DOI: https://doi.org/10.1007/BF02594850

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