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The combined action of p-aminosalicylic acid and streptomycin with isonicotinic acid hydrazide in vitro

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Summary

A method is described of investigating and representing graphically the simultaneous action of two antibacterial agents. The results are reported of the investigation with the H37Rv strain and the PAS and INH resistant forms obtained from this strain on mixtures of PAS and INH, and the results of the investigation with the H37Rv strain and the streptomycin and INH resistant forms obtained on mixtures of streptomycin and INH. It appears that there is a definite synergism in mixtures containing about 99% PAS and 1% INH. Additivity, to slight antagonism, is found in mixtures consisting of streoptomycin and INH.

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Authors and Affiliations

  1. Department for Internal Diseases, The University Hospital, Leyden

    A. J. Zwart Voorspuij & C. A. G. Nass

  2. The Statistical Department of the Institute for Preventive Medicine, Leyden

    A. J. Zwart Voorspuij & C. A. G. Nass

  3. The Research Department of N. V. Koninklijke Pharmaceutische Fabrieken v/h Brocades-Stheeman & Pharmacia, Amsterdam

    A. J. Zwart Voorspuij & C. A. G. Nass

Authors
  1. A. J. Zwart Voorspuij
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  2. C. A. G. Nass
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Additional information

This research was supported in part by Riker Laboratories Inc., Los Angelos, California.

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Zwart Voorspuij, A.J., Nass, C.A.G. The combined action of p-aminosalicylic acid and streptomycin with isonicotinic acid hydrazide in vitro. Antonie van Leeuwenhoek 19, 225–236 (1953). https://doi.org/10.1007/BF02594849

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  • DOI: https://doi.org/10.1007/BF02594849

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