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Resistance in Mycobacteria to viomycin

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Summary

Three strains of mycobacteria were made resistant to viomycin. As compared with the normally sensitive parent strain, the increase in resistance obtained was ca. 100 times inMyc. phlei, whereas inMyc. avium andMyc. tuberculosis H37Rv resistance levels of only 10 or 20 times the normal value could be reached. A high degree of viomycin resistance induced at the same time cross resistance to neomycin, aureomycin and terramycin, and, to a lesser extent, also to streptomycin and choloromycetin. No cross resistance could be established in strains of lower resistance levels. The species investigated followed the multi-step penicillin pattern in their developing resistance.

An explanation of the phenomena described is given on the assumption that resitance originates from successive mutations comprising more genes as resistance is raised to a higher level.

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Authors and Affiliations

  1. National Institute of Public Health, Utrecht

    A. Manten & L. J. Van Wijngaarden

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  1. A. Manten
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  2. L. J. Van Wijngaarden
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Manten, A., Van Wijngaarden, L.J. Resistance in Mycobacteria to viomycin. Antonie van Leeuwenhoek 19, 93–99 (1953). https://doi.org/10.1007/BF02594835

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