Summary
Cytomegalovirus has been suggested as a co-factor of disease progression in patients with human immunodeficiency virus type 1 infection. Cytomegalovirus infection is highly prevalent among populations at risk of human immunodeficiency virus 1 infection, and has been associated with both an increased susceptibility to infection and a more rapid course of the disease towards immunodeficiency. Cytomegalovirus can have a direct immunosuppressive effect (through infection of immune cells) and can enhance the replication of human immunodeficiency virus (through the transactivation of the genic immunodeficiency virus expression, the stimulation of cytokine production, and the increase in Fc receptor expression on target cells). The role of cytomegalovirus as a co-factor of the progression towards immunodeficiency in subjects infected with the human immunodeficiency virus type 1 needs to be elucidated with more extensive clinical studies and the application of new molecular biology techniques.
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References
Barry PA, Pratt-Lowe E, Peterlin BM, Luciw PA, Cytomegalovirus activates transcription directed by the long terminal repeat of human immunodeficiency virus type 1. J Virol 64:2932, 1990
Belec L, Gray F, Mikol J, Scaravilli F, Mhiri C, Sobel A, Poirier J, Cytomegalovirus encephalomyeloradiculitis and human immunodeficiency virus encephalitis: presence of HIV and CMV co-infected multinucleated giant cells. Acta Neuropathol (Berl) 81:99, 1990
Biegalke BJ, Geballe AP, Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus. Virology 183:381, 1991
Bonetti A, Weber R, Vogt MW, Wunderli W, Siegenthaler W, Luthy R, Co-infection with human immunodeficiency virus-type 1 (HIV-1) and cytomegalovirus in two intravenous drug users. Ann Intern Med 111:293, 1989
Carney WP, Iacoviello V, Hirsch MS, Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis. J Immunol 130:390, 1983
Clouse KA, Robbins FB, Fernie B, Ostrove JM, Fauci AS, Viral antigen stimulation of the production of human monokines capable of regulating HIV-1 expression. J Immunol 143:470, 1989
Davis MG, Kenney SC, Kamine J, Pagano JS, Huang E-S, Immediate-early gene region of human cytomegalovirus transactivates the promoter of human immunodeficiency virus. Proc Natl Acad Sci USA 84:8642, 1987
Drew WL, Other virus infections in AIDS. In: Levy JA (ed) AIDS, pathogenesis and treatment. Dekker, New York, pp 507–534, 1989
Drew WL, Mills J, Levy J, Dylewski J, Casavant C, Ammann AJ, Brodie H, Merigan T, Cytomegalovirus infections and abnormal T-lymphocyte subset ratios in homosexual men. Ann Intern Med 103:61, 1985
Finkle C, Tapper MA, Knox KK, Carrigan DR, Coinfection of cells with the human immunodeficiency virus and cytomegalovirus in lung tissues of patients with AIDS. J Acquir Immune Defic Syndr 4:735, 1991
Golden MP, Kim S, Hammer SM, Ladd EA, Schaffer PA, DeLuca N, Albrecht MA, Activation of human immunodeficiency virus by herpes simplex virus. J Infect Dis 166:494, 1992
Ho W-Z, Harouse JM, Rando RF, Gonczol E, Srinivasan A, Plotkin SA, Reciprocal enhancement of gene expression and viral replication between human cytomegalovirus and human immunodeficiency virus type 1. J Gen Virol 71:97, 1990
Jackson JB, Erice A, Englund JA, Edson JR, Balfour HH Jr, Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1. Transfusion 28:187, 1988
Jacobson MA, Mills J, Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 108:585, 1988
Levy E, Margalith M, Sarov B, Sarov I, Rinaldo CR, Detels R, Phair J, Karlow R, Ginsburg H, Saah AJ, Cytomegalovirus IgG and IgA serum antibodies in a study of HIV infection and HIV related diseases in homosexual men. J Med Virol 35:174, 1991
Lusso P, Ensoli B, Markham PD, Ablashi DV, Salahuddin SZ, Tschachler E, Wong-Staal, Gallo RC, Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337:370, 1989
McKeating JA, Griffiths PD, Weiss RA, HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor. Nature 343:659, 1990
Mintz L, Drew WL, Miner RC, Braff EH, Cytomegalovirus infections in homosexual men. Ann Intern Med 99:326, 1983
Mosca JD, Bednarik DP, Ray NBK, Rosen CA, Sodroski JG, Haseltine WA, Hayward GS, Pitha PM, Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to atrans-acting factor encoded by herpes simplex virus 1. Proc Natl Acad Sci USA 84:7408, 1987
Nelson JA, Reynolds-Kohler C, Oldstone MBA, Wiley CA, HIV and HCMV coinfect brain cells in patients with AIDS. Virology 165:286, 1988.
Nigro G, Castelli Gattinara G, Mattia S, Elia L, Livadiotti S, Midulla M, Progression towards AIDS in children with congenital HIV-cytomegalovirus coinfection (abstract). Abstracts of the VIIth International Conference on AIDS. Florence, 16–21 June, p 350, 1991
Paya CV, Virelizier J-L, Michelson S, Modulation of T-cell activation through protein kinase C- or A-dependent signalling pathways synergistically increases human immunodeficiency virus long terminal repeat induction by cytomegalovirus immediate-early proteins. J Virol 65:5477, 1991
Peterson PK, Gekker G, Chao CC, Hu S, Edelman C, Balfour HH Jr, Verhoef J, Human cytomegalovirus-stimulated peripheral blood mononuclear cells induce HIV-1 replication via a tumor necrosis factor-α-mediated mechanism. J Clin Invest 89:574, 1992
Polk, BF, Fox R, Brookmeyer R, Kanchanaraksa S, Kaslow R, Visscher B, Rinaldo C, Phair J, Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men. N Engl J Med 316:61, 1987
Rando RF, Pellet PE, Luciw PA, Bohan CA, Srinivasan A, Transactivation of human immunodeficiency virus by herpesviruses. Oncogene 1:13, 1987
Rando RF, Srinivasan A, Feingold J, Gonczol E, Plotkin S, Characterization of multiple molecular interactions between human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Virology 176:87, 1990
Rice GPA, Schrier RD, Oldstone MBA, Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products. Proc Natl Acad Sci USA 81:6134, 1984
Schrier RD, Nelson JA, Oldstone MBA, Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science 230:1048, 1985
Skolnik PR, Kosloff BR, Hirsch MS, Bidirectional interactions between human immunodeficiency virus type 1 and cytomegalovirus. J Infect Dis 157:508, 1988
Smith PD, Saini SS, Raffeld M, Manischewitz JF, Wahl SM, Cytomegalovirus induction of tumor necrosis factor-α by human monocytes and mucosal macrophages. J Clin Invest 90:1642, 1992
Taylor-Wiedeman J, Sissons JGP, Borysiewicz LK, Sinclair JH, Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 72:2059, 1991
Turtinen LW, Saltzman R, Jordan MC, Haase AT, Interactions of human cytomegalovirus with leukocytes in vivo: analysis by in situ hybridization. Microbiol Pathol 3:287, 1987
Webster A, Lee CA, Cook DG, Grundy JE, Emery VC, Kernoff PBA, Griffiths PD, Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet II:63, 1989
Wong-Staal F, Human immunodeficiency viruses and their replication. In: Fields BN, Knipe DM (eds) Virology. Raven, New York, pp 1529–1543, 1990
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Nardiello, S., Digilio, L., Pizzella, T. et al. Cytomegalovirus as a co-factor of disease progression in human immunodeficiency virus type 1 infection. Int J Clin Lab Res 24, 86–89 (1994). https://doi.org/10.1007/BF02593905
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DOI: https://doi.org/10.1007/BF02593905