Summary
This paper gives the results for HBeAg and anti-HBe titers in chronic HBsAg carriers and patients with type B hepatitis using a “solid-phase” radioimmunoassay.
In tumor and hemodialysis patients the HBeAg titers are statistically significant higher compared to the group of HBsAg positive CAH or CPH.
High anti-HBe titers are a characteristic finding in “healthy” HBsAg carriers. On the other hand, there is a subgroup of HBsAg positive CAH with anti-HBe; although there are signs of an ongoing virus B replication these cases of CAH proceed sometimes to cirrhosis.
Zusammenfassung
In dieser Arbeit werden die Ergebnisse der HBeAg und anti-HBe-Titer Bestimmungen mit einem „solid-phase“-Radioimmunoassay dargestellt.
Bei Tumor- und Hämodialysepatienten sind die HBeAg-Titer statistisch signifikant höher als bei Patienten mit HBsAg positiver CAH oder CPH.
Hohe anti-HBe Titer sind ein charakteristischer Befund für „gesunde“ HBsAg-Träger. Andererseits gibt es eine Untergruppe der HBsAg positiven CAH mit anti-HBe; obgleich bei dieser Form eine CAH keine Zeichen einer fortbestehenden Virus B-Replikation nachgewiesen werden kann, schreitet die Krankheit manchmal in Richtung auf eine Zirrhose fort.
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Dedicated to Prof. Dr. P. Schölmerich, on his 65th birthday
Supported by the Deutsche Forschungsgemeinschaft, grant no Ar 106/3
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Arnold, W., Hess, G., Kawakami, H. et al. Quantitation of HBeAG and anti-HBe by RIA in sera of chronic HBsAG carriers and individuals with Type B hepatitis. Klin Wochenschr 59, 679–683 (1981). https://doi.org/10.1007/BF02593860
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DOI: https://doi.org/10.1007/BF02593860