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Lasers in Medical Science

, Volume 3, Issue 1–4, pp 99–102 | Cite as

Detection of near-infrared porphyrin fluorescence excited in experimental animal tumour by the HeNe laser

  • M. Zandomeneghi
  • C. Festa
  • C. A. Angelletti
  • G. Menconi
  • T. Sicuro
  • I. Cozzani
Article

Abstract

The red emission (632 nm) of a low-power (about 10 mW) HeNe laser is used to excite liposome-bound haematoporphyrin dimethylester localized in a solid tumour implanted in the mouse leg (MS-2 sarcoma). Fluorescence from the target area, filtered at >710 nm, is converted into visible green light by means of a near-infrared-visible image converter. The photographically recorded images clearly reveal differences in fluorescence intensity of tumour tissues with respect to normal tissues. Clinical application of the procedure is proposed, and the expected advantage with respect to current fluorescence endoscopy are discussed.

Keywords

Haematoporphyrin Red light laser Fluorescence endoscopy Tumour detection 

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Copyright information

© Baillière Tindall 1988

Authors and Affiliations

  • M. Zandomeneghi
    • 1
  • C. Festa
    • 1
  • C. A. Angelletti
    • 2
  • G. Menconi
    • 2
  • T. Sicuro
    • 3
  • I. Cozzani
    • 3
  1. 1.Dipartimento di Chimica e Chimica Industriale dell'Università di PisaPisaItaly
  2. 2.Clinical Chirurgical Generale dell'Università di PisaItaly
  3. 3.Cattedra di Biochimica ApplicataFacoltà di Medicina e Chirurgia dell'Università di Reggio CalabriaItaly

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