Advertisement

Lasers in Medical Science

, Volume 3, Issue 1–4, pp 41–45 | Cite as

Molecular aspects in tumour photochemotherapy

  • D. Brault
Article

Abstract

Photochemotherapy is based on the selective retention by tumours of a photosensitizer which can then be inactivated upon local irradiation by visible laser light. The process involves the photosensitized generation of reactive intermediate species, such as singlet oxygen, with deleterious effects on the diseased tissues. Some fundamental aspects relevant to this new method are examined. Emphasis is given to the interactions of photosensitizers with membranes and to directions for the development of more efficient molecules.

Key words

Photochemotherapy Tumours 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Policard A. Etudes sur les aspects offerts par des tumeurs expérimentales examinées à la lumière de Woods.CR Séanc Soc Biol 1924,91:1423–4Google Scholar
  2. 2.
    Lipson RL, Baldes EJ, Olsen AM. The use of a derivative of hematoporphyrin in tumor detection.J Natl Cancer Inst 1961,26:1–11PubMedGoogle Scholar
  3. 3.
    Dougherty TJ, Lawrence G, Kaufman JH et al. Photoradiation in the treatment of recurrent breast carcinoma.J Natl Cancer Inst 1979,62:231–7PubMedGoogle Scholar
  4. 4.
    Hayata Y, Kato H, Konaka C et al. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.Chest 1982,81:269–77PubMedGoogle Scholar
  5. 5.
    Patrice T, Jutel P, Foultier MT et al. Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology.Eur J Cancer Clin Oncol 1987,23:509–12PubMedCrossRefGoogle Scholar
  6. 6.
    Kessel D, Dougherty TJ, (eds), Porphyrin photosensitization. Proceedings of a Porphyrin Photosensitization Workshop, 28–29 September 1981, Washington, DC. New York: Plenum Press, 1983Google Scholar
  7. 7.
    Andreoni A, Cubeddu R, (eds). Porphyrins in tumor phototherapy. Proceedings of the International Symposium on Porphyrins in Tumor Phototherapy, 16–28 May 1983, Milan. New York: Plenum Press, 1984Google Scholar
  8. 8.
    Doiron DR, Gomer CJ (eds). Porphyrin localization and treatment of tumors. Proceedings of the Clayton Foundation International Symposium on Porphyrin Localization and Treatment of Tumors, 26–28 April 1983, Santa Barbara. New York: Alan R. Liss, 1984Google Scholar
  9. 9.
    Jori G, Perria C (eds). Photodynamic therapy of tumors and other diseases. Proceedings of the Meeting on Porphyrins as Phototherapeutic Agents for Tumors and Other Diseases, 1–4 May 1985, Alghero, Italy. Padova, Italy: Libreria Progetto, 1985Google Scholar
  10. 10.
    Kessel D (ed).Methods in Porphyrin Photosensitization II. New York: Plenum Press, 1985Google Scholar
  11. 11.
    Jori G, Spikes J. Photobiochemistry of porphyrins. In: Smith KC (ed).Topics in photomedicine. New York: Plenum, 1984:183Google Scholar
  12. 12.
    Bonnett R, Charalambides AA, Land EJ et al. Triplet states of porphyrin esters.J Chem Soc Faraday I 1980,76:852–9CrossRefGoogle Scholar
  13. 13.
    Rougée M, Bensasson R. Determination des constantes de vitesse de désactivation de l'oxygène singulet en présence de biomolécules.CR Acad Sc Paris Série II 1986,302:1223–6Google Scholar
  14. 14.
    Keene JP, Kessel D, Land EJ et al. Direct detection of singlet oxygen sensitized by haematoporphyrin and related compounds.Photochem Photobiol 1986,43:117–20PubMedGoogle Scholar
  15. 15.
    Weishaupt KR, Gomer CJ, Dougherty TJ. Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor.Cancer Res 1976,36:2326–9PubMedGoogle Scholar
  16. 16.
    Salet C, Moreno G, Vever-Bizet C, Brault D. Anoxic photodamage in the presence of porphyrins: evidence for the lack of effects on mitochondrial membranes.Photochem Photobiol. 1984,40:145–7PubMedGoogle Scholar
  17. 17.
    Smith KC. New topics in photobiology. In: Smith KC (ed).The science of photobiology, New York: Plenum, 1977:397–417Google Scholar
  18. 18.
    Bonnett R, Ridge RJ, Scourides PA, Berenbaum MC. On the nature of haematoporphyrin derivative.J Chem Soc Perkin Trans I 1981, 3135–40Google Scholar
  19. 19.
    Dellinger M, Brault D. Normal-phase high-performance liquid chromatography of free acid dicarboxylic porphyrins and hematoporphyrin derivative on silica.J Chromatogr Biomed Appl 1987,422:73–84CrossRefGoogle Scholar
  20. 20.
    Dougherty TJ, Potter WR, Weishaupt KR. The structure of the active component of hematoporphyrin derivative. In ref. 7 pp. 23–35Google Scholar
  21. 21.
    Kessel D. Proposed structure of the tumor-localizing component of hematoporphyrin derivatives. In ref. 9, pp. 1–7Google Scholar
  22. 22.
    Xun S, Suzhen P, Yin Z et al. Cellular uptake of different components in HpD.Photobiochem Photobiophys 1986,13:165–76Google Scholar
  23. 23.
    Kessel D. Components of hematoporphyrin derivatives and their tumor-localizing capacity.Cancer Res 1982,42:1703–6PubMedGoogle Scholar
  24. 24.
    Berns MW, Dahlman A, Johnson FM et al. In vitro cellular effects of hematoporphyrin derivative.Cancer Res 1982,42:2325–9PubMedGoogle Scholar
  25. 25.
    Dellinger M, Vever-Bizet C, Brault D et al. Cellular uptake of hydroxyethylvinyldeuteroporphyrin (HVD) and photoinactivation of cultivated human leukemia (Reho) cells.Photochem Photobiol 1986,43:639–47PubMedGoogle Scholar
  26. 26.
    Kessel D. Hematoporphyrin and HpD: photophysics, photochemistry and phototherapy.Photochem Photobiol 1984,39:851–9PubMedGoogle Scholar
  27. 27.
    Moan J. Porphyrin photosensitization and phototherapy (1986).Photochem Photobiol 1986,43:681–90PubMedGoogle Scholar
  28. 28.
    Winkelman J. The distribution of tetraphenylporphine-sulfonate in the tumor-bearing rat.Cancer Res 1962,22:589–96PubMedGoogle Scholar
  29. 29.
    Kessel D, Thompson P, Saatio K, Nantwi KD. Tumor localization and photosensitization by sulfonated derivatives of tetraphenylporphine.Photochem Photobiol 1987,45:787–90PubMedGoogle Scholar
  30. 30.
    Kessel D. Effects of photoactivated porphyrins at the cell surface of leukemia L1210 cells.Biochemistry 1977,16:3443–9PubMedCrossRefGoogle Scholar
  31. 31.
    Brault D, Vever-Bizet C, Le Doan T. Spectrofluorimetric study of porphyrin incorporation into membrane models—evidence for pH effects.Biochim Biophys Acta 1986,857:238–50PubMedCrossRefGoogle Scholar
  32. 32.
    Brault D, Vever-Bizet C, Dellinger M. Fundamental aspects in tumor photochemotherapy: interactions of porphyrins with membrane model systems and cells.Biochimie 1986,68:913–21PubMedCrossRefGoogle Scholar
  33. 33.
    Bohorquez M, Patterson LK, Brault D. Porphyrin-lipid interactions at the air-water interface in spread monolayers. A fluorescence study.Photochem Photobiol 1987,46:953–7PubMedGoogle Scholar
  34. 34.
    Spikes JD. Phthalocyanines as photosensitizers in biological systems and for the photodynamic therapy of tumors.Photochem Photobiol 1986,43:691–9PubMedGoogle Scholar
  35. 35.
    Tralau CJ, MacRobert AJ, Coleridge-Smith PD et al. Photodynamic therapy with phthalocyanine sensitization: quantitative studies in a transplantable rat fibrosarcoma.Br J Cancer 1987,55:389–95PubMedGoogle Scholar
  36. 36.
    Brault D, Vever-Bizet C, Rougée M, Bensasson R. Photophysical properties of a chlorin, a potent sensitizer for photochemotherapy.Photochem Photobiol 1987,47:151–4Google Scholar
  37. 37.
    Andreoni A, Cubeddu R, De Silvestri S et al. Two-step laser activation of hematoporphyrin derivative.Chem Phys Lett 1982,88:37–9CrossRefGoogle Scholar
  38. 38.
    Andreoni A, Cubeddu R, Svelto O. Pulsed laser photoactivation of porphyrins. In ref. 9, pp. 37–43Google Scholar
  39. 39.
    Spears JR, Serur J, Shropshire D, Paulin S. Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative.J Clin Invest 1983,71:395–9PubMedCrossRefGoogle Scholar
  40. 40.
    Pernes JM, Brault D, Angel CY et al. Comparative study of the selective uptake of hematoporphyrin derivative components into experimental atheromatous plaques: potential for laser angioplasty.J Intervent Radiol 1988, in pressGoogle Scholar

Copyright information

© Baillière Tindall 1988

Authors and Affiliations

  • D. Brault
    • 1
  1. 1.Laboratoire de Biophysique, INSERM U.201, CNRS UA.481Muséum National d'Histoire NaturelleParisFrance

Personalised recommendations