Advertisement

Lasers in Medical Science

, Volume 3, Issue 1–4, pp 21–25 | Cite as

Porphyrin-sensitized phototreatment as a conservative therapy in gynaecological oncology

  • A. Gadducci
  • V. Facchini
  • A. Tau
  • L. Colombi
  • P. Fioretti
  • M. F. Vigna
  • I. Cozzani
Article
  • 20 Downloads

Abstract

Three patients having neoplastic lesions of the lower genital tract were treated by photodynamic therapy, using haematoporphyrin IX hydrochloride as sensitizer and a non-coherent red light. Irradiations were performed at 12, 24, 48 and 72 h from dye injection for 15 min at a fluence of 0.6 W/cm2. The successful outcome of the therapy and the prospects for photodynamic therapy in gynaecological oncology are discussed.

Keywords

Haematoporphyrin Photodynamic therapy Photonecrosis Gynaecological oncology 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dougherty T, Kaufman J, Goldfarb A et al. Photoradiation therapy for the treatment of malignant tumors.Cancer Res 1978,38:2628–35PubMedGoogle Scholar
  2. 2.
    Dougherty T. Hematoporphyrin as a photosensitizer of tumors.Photochem Photobiol 1981,38:377Google Scholar
  3. 3.
    Dougherty T. Hematoporphyrin derivative for detection and treatment of cancer.J Surg Oncol 1980,15:209–10PubMedCrossRefGoogle Scholar
  4. 4.
    Cortese DA, Kinsey F, Woolner RB et al. Clinical applications of a new endoscopic technique for detection of in situ bronchial carcinoma.Mayo Clin Proc 1979,34:635–41Google Scholar
  5. 5.
    Hayata Y, Kato H, Komaca C et al. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.Chest 1982,81:269–77PubMedGoogle Scholar
  6. 6.
    Cozzani I, Facchini V, Gadducci A et al. Uptake and clearance of hematoporphyrin administered to patients with gynecologic neoplasias: molecular mechanisms and clinical prospects.Med Biol Env 1983,11:403–9Google Scholar
  7. 7.
    Fioretti P, Facchini V, Gadducci A, Cozzani I. Monitoring of hematoporphyrin injected in humans and clinical prospects of its use in gynecologic oncology. In: Andreoni A, Cubeddu R (eds)Porphyrin in tumor phototherapy. New York: Plenum Press, 1984:355–61Google Scholar
  8. 8.
    Facchini V, Gadducci A, Colombi L et al. Fluorescence detection and porphyrin sensitized phototreatment of gynecologic tumors. In: Jori G, Perria C (eds)Photodynamic therapy of tumors and other diseases. Padova: Libreria Progetto, 1985:333–6Google Scholar
  9. 9.
    Facchini V, Gadducci A, Tau A et al. Diagnostic and therapeutic applications of porphyrin with visible light in gynecological oncology.Med Biol Enu 1985,13:61–3Google Scholar
  10. 10.
    Facchini V, Gadducci A, Colombi L et al. Photodynamic therapy of gynecologic tumors.Med Biol Env 1986,14:87–9Google Scholar
  11. 11.
    Cozzani I, Jori G, Reddi E et al. Interaction of free and liposome-bound porphyrin with normal and malignant cells: biochemical and photosensitization studies in vitro and in vivo. In: Andreoni A, Cubeddu R (eds)Porphyrin in tumor phototherapy. New York: Plenum Press, 1984:157–65Google Scholar
  12. 12.
    Mosca F, Parra PF, Brandi LS et al. Selective location of porphyrins in neoplastic and pre-neoplastic lesions of large intestine. In: Jori G, Perria C (eds)Photodynamic therapy of tumors and other diseases. Padova: Libreria Progetto, 1985:207–10Google Scholar
  13. 13.
    Tomio L, Zorat PL, Corti L et al. Cancer phototherapy: biochemical bases and experimental results.Med Biol Env 1982,10:303–7Google Scholar
  14. 14.
    Corti L, Tomio L, Calzavara F et al. Evaluation of hematoporphyrin photodynamic therapy to treat malignant tumors. In: Jori G, Perria C (eds)Photodynamic therapy of tumors and other diseases. Padova: Libreria Progetto, 1985:317–20Google Scholar
  15. 15.
    Jori G, Reddi E, Cozzani I, Tomio L. Controlled targeting of different subcellular sites by porphyrins in tumor bearing mice.Br J Cancer 1986,53:615–21PubMedGoogle Scholar
  16. 16.
    Waldow SM, Dougherty TJ. Interaction of hyperthermia and photoradiation therapy.Radiat Res 1984,97:380–5PubMedCrossRefGoogle Scholar
  17. 17.
    Cozzani I, Vigna MF, Zandomeneghi M et al. Biochemical and biophysical factors controlling porphyrin-sensitized photodynamic action in isolated cells and in spontaneous tumors. In: Jori G, Perria C (eds)Photodynamic therapy of tumors and other diseases. Padova: Libreria Progetto, 1985:149–52Google Scholar
  18. 18.
    Lucas WE, Benirschke K, Lebherz TB. Verrucous carcinoma of the female genital tract.Am J Obstet Gynecol 1974,119:435–40PubMedGoogle Scholar
  19. 19.
    Richart RM. Natural history of cervical intraepithelial neoplasia.Clin Obst Gynaecol 1967,10:748–84CrossRefGoogle Scholar
  20. 20.
    Fioretti P, Gadducci A, Menchini-Fabris GS, Melis GB. Liquido seminale e vie genitali femminili.Atti I Congr Naz Soc It Andrologia, Pisa, 1978:49–67Google Scholar

Copyright information

© Baillière Tindall 1988

Authors and Affiliations

  • A. Gadducci
    • 1
  • V. Facchini
    • 1
  • A. Tau
    • 1
  • L. Colombi
    • 1
  • P. Fioretti
    • 1
  • M. F. Vigna
    • 2
  • I. Cozzani
    • 2
  1. 1.Istituto di Clinica Ginecologica ed Ostetrica dell'Università di PisaItaly
  2. 2.Cattedra di Biochimica ApplicataFacoltà di Medicina e Chirurgia dell'Università di Reggio CalabriaItaly

Personalised recommendations