Summary
Fibrin generation and lysis were studied in 28 patients with angina pectoris (14 with active disease and 14 with inactive disease) and in 14 normal controls. The fibrinolytic response was evaluated by comparing the ratio between the plasma levels of fibrinopeptide A and fibrin degradation products. Levels of both were higher in patients than in controls (P<0.001), with higher levels in active than in inactive disease (P<0.001). The fibrinopeptide A/fibrin degradation products ratio was much higher (P<0.001) in the active group than in other groups. Thus, in patients with angina pectoris, especially in the active state, the increased thrombin generation is not paralleled by an equivalent increase in fibrinolytic activity.
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Nossel HL, Ti M, Kaplan K, Spanondis K, Solant T, Butler VP Jr. The generation of fibrinopeptide A in clinical blood samples. Evidence for thrombin activity. J Clin Invest 1976; 58: 1136.
Neri Serneri GG, Gensini GF, Abbate R, Mugnaini C, Favilla S, Brunelli C, Chierchia S, Parodi O. Increased FPA and TxB2 formation in patients with ischemic heart disease: relationship to coronary pathoanatomy, risk factors and clinical manifestations. Am Heart J 1981; 101: 185.
Neri Serneri GG, Gensini GF, Carnovali M, Prisco D, Rogasi PG, Casolo GC, Fazi A, Abbate R. Association between time of increased fibrinopeptide A levels in plasma and episodes of spontaneous angina: a controlled prospective study. Am Heart J 1987; 113: 672.
Neri Serneri GG, Abbate R, Prisco D, Carnovali M, Fazi A, Casolo GC, Bonechi F, Rogasi PG, Gensini GF. Decrease in frequency of anginal episodes by control of thrombin generation with low-dose heparin: a controlled cross-over randomized study. Am Heart J 1988; 115: 60.
Small M, Lowe GDO, Douglas JT, Hutton I, Lorimer AR, Forbes CD. Thrombin and plasmin activity in coronary artery disease. Br Heart J 1988; 60: 201.
Theroux P, Latour JG, Leger-Gauthier C, De Lara J. Fibrinopeptide A and platelet factor 4 levels in unstable angina pectoris. Circulation 1987; 75: 156.
Merlini PA, Bauer KA, Oltrona L, Ardissino D, Cattaneo M, Belli C, Mannucci PM, Rosenberg RD. Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 1994; 90: 61.
Hamsten A, Wiman B, Faire U de, Blomback M. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med 1985; 313: 1557.
Hamsten A, Faire U de, Walldius G, Szamosi A, Landou C, Blomback M, Wiman B. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 1987; II: 3
Prins MH, Hirsh J. A critical review of the relationship between impaired fibrinolytic activity and myocardial infarction. Am Heart J 1991; 122: 545.
Kruskal JB, Commerford PJ, Franks JJ, Kirsch FE. Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease. N Engl J Med 1987; 317: 1361.
Prisco D, Paniccia R, bonechi F, Francalanci I, Abbate R, Gensini GF. Evaluation of new methods for the selective measurement of fibrin and fibrinogen degradation products. Thromb Res 1989; 56: 547
Kockum C, Frebelius S. Rapid radioimmunoassay of human fibrinopeptide A. Removal of cross-reactivity fibrinogen with bentonite. Thromb Res 1980; 19: 589.
Amiral J, Walenga JM, Fareed J. Development and performance characteristics of a competitive enzyme immunoassay for fibrinopeptide A. Semin Thromb Hemost 1984; 10: 228.
Koppert PW, Hoegee-de Nobel E, Niewenhuizen WA. A monoclonal antibody based enzyme immunoassay for fibrin degradation products in plasma. Thromb Haemost 1988; 59: 310.
Alexopoulos D, Ambrose JA, Stump D, Borrico S, Gorlin R, Pramod D, Fisher EA. Thrombosis-related markers in unstable angina pectoris. J Am Coll Cardiol 1991; 4: 866.
Donati MB. Assays for fibrinogen-fibrin degradation products in biological fluids. Some methodological aspects. Thromb Diath Haemorrh 1975; 34: 652.
Nossel HL, Yudelman I, Confield RE, Butler VP Jr, Spanondis K, Wilner GD, Qureshi GD. Measurement of fibrinopeptide A in human blood. J Clin Invest 1974; 54: 43.
Franks JJ, Kirsh RE, Kao B, Kloppel TM. Fibrinogen and fibrinogen related peptides in cancer. In: Mariani G, Pathophysiology of plasma protein metabolism London: Macmillan; 1984: 265–269.
Gallino A, Haeberli A, Bauer HR, Straub PW. Fibrin formation and platelet aggregation in patients with severe coronary artery disease: relationship with the degree of myocardial ischemia. Circulation 1985; 72: 27.
Neri Serneri GG, Abbate R, Gori AM, Attanasio M, Martini F, Giusti B, Dabizzi P, Poggesi L, Modesti PA, Trotta F, Rostagno C, Boddi M, Gensini GF. Transient intermittent lymphocyte activation is responsible for the instability of angina. Circulation 1992; 86: 790.
Masuda T, Yasue H, Ogawa H, Misumi I, Sakamoto T, Okubo H, Miyao Y, Kato H. Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina. Am Heart J 1992; 124: 314.
Colucci M, Paramo JA, Stassen JM, Collen D. Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. J Clin Invest 1986; 78: 138.
De Fouw NJ, De Jong YF, Haverkate F, Bertina RM. The influence of thrombin and platelets on fibrin clot lysis rates in vitro: a study using a clot lysis system consisting of purified human proteins. Fibrinolysis 1988; 2: 235.
Sakata K, Chinori K, Kobayashi A, Rydzewsky A, Yamazaki N. Plasminogen activator inhibitor activity as a possible indicator of disease activity in rest angina with angiographically insignificant coronary artery stenosis. Thromb Res 1991; 63: 491.
Knabb RM, Chiu AT, Reilly TM. Effect of recombinant plasminogen activator inhibitor type-1 on fibrinolysis in vitro and in vivo. Throm Res 1990; 59: 309.
Schwartz BS, Bradshaw JD. Regulation of plasminogen activator inhibitor mRNA levels in lipopolysaccharide-stimulated human monocytes. J Biol Chem 1992; 267: 7089.
Heng MK, Norris RM, Singh BN, Partridge JB. Prognosis in unstable angina. Br Heart J 1976; 38: 921.
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Prisco, D., Paniccia, R., Francalanci, I. et al. Fibrin generation and digestion in patients with angina pectoris. Int J Clin Lab Res 25, 222–225 (1995). https://doi.org/10.1007/BF02592702
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DOI: https://doi.org/10.1007/BF02592702