Antibody-mediated neutropenia following bone marrow transplantation


Unexpected neutropenia following allogeneic or autologous bone marrow transplantation may be caused by graft rejection, intrinsic stem cell failure, infection, graft-versus-host disease, relapse of the underlying neoplasm, or drug-induced myelosuppression. Over the past decade an increasing number of reports have documented that the differential diagnosis also includes antibody-mediated neutropenia, a syndrome distinct from conventional graft rejection. In constrast to many of the other common causes of unexpected post-transplant neutropenia, antibody-mediated neutropenia usually responds well to treatment with corticosteroids, plasma exchange, intravenous immunoglobulin, splenectomy, or other similar measures.

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Klumpp, T.R. Antibody-mediated neutropenia following bone marrow transplantation. Int J Clin Lab Res 23, 4–7 (1993).

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Key words

  • Bone marrow transplantation
  • Neutropenia
  • Neutrophils
  • Autoimmunity