Skip to main content
SpringerLink
Log in

Young Investigator Award Presentation at the 13th Annual Meeting of the ESMRMB, September 1996, Prague Quantification of pulmonary water compartments by magnetic resonance

  • Papers
  • Published:
Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

The purpose of this study was to quantify pulmonary water compartments of total, intravascular, and extravascular lung water in excised and perfused sheep lungs with the use of magnetic resonance imaging techniques. Total lung water was measured by proton density maps calculated from multi-spin-echo images. Intravascular lung water was evaluated by magnetic resonance angiography before and after injection of gadolinium diethylenetriamine penta-acetic acid polylysine, a macromolecular paramagnetic contrast agent. Intravascular lung water was calculated from signal intensity histogram changes comparing pre- and postcontrast angiograms. Extravascular water was calculated as the difference between total and intravascular lung water. Quantities of total and intravascular lung water measured by magnetic resonance techniques were compared to reference results obtained from wet/dry weight gravimetry and Evans blue dilution performed after imaging. Magnetic resonance and reference results correlated significantly (total lung water:r=0.93,p<0.001; intravascular lung water:r=0.80,p<0.001; extravascular lung water:r=0.89,p<0.001). Therefore, we conclude that quantitative magnetic resonance techniques are potentially useful for the clinical evaluation of pulmonary water compartments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Chinard FP (1975) Estimation of extravascular water by indicator-dilution techniques.Circ Res 37: 137–145.

    PubMed  CAS  Google Scholar 

  2. Böck JC, Lewis F (1990) Research review: clinical relevance of lung water measurement with the thermaldye dilution technique.J Surg Res 48: 254–265.

    Article  PubMed  Google Scholar 

  3. Halperin BD, Feeley TW, Mihm FG, Chiles C, Guthaner DF, Blank NE (1980) Evaluation of the portable chest roentgenogram for quantitating extravascular lung water in critically ill adults.Chest 88: 649–652.

    Google Scholar 

  4. Laggner A, Kleinberger G, Haller J, Lenz K, Sommer G, Druml W (1984) Bedside estimation of extravascular lung water in critically ill patients: comparison of the chest radiograph and the thermal-dye technique.Intensive Care Med 10: 309–313.

    Article  PubMed  CAS  Google Scholar 

  5. Stark P, Jasmine J (1989) CT of pulmonary edema.Crit Rev Diagnostic Imaging 29: 245–255.

    CAS  Google Scholar 

  6. MacLennan FM, Foster MA, Smith FW, Crosher GA (1986) Measurement of total lung water from nuclear magnetic resonance images.Brit J Radiol 59: 553–560.

    Article  PubMed  CAS  Google Scholar 

  7. Mayo JR, MacKay AL, Whittall KP, Baile EM, Pare PD (1995) Measurement of lung water content and pleural pressure gradient with magnetic resonance imaging.J Thorac Imaging 10: 73–81.

    Article  PubMed  CAS  Google Scholar 

  8. Skalina S, Kundel HL, Wolf G, Marshall B (1984) The effect of pulmonary edema on proton nuclear magnetic resonance relaxation times.Invest Radiol 19: 7–9.

    Article  PubMed  CAS  Google Scholar 

  9. Kundel HL, Shetty A, Joseph PM, Summers RM, Kassab EA, Moore B (1988) Sodium NMR imaging of lung water in rats.Magn Reson Med 6: 381–389.

    Article  PubMed  CAS  Google Scholar 

  10. Wlodarczyk W, Böck JC, Sander B, Bittner R, Felix R (1992) Ein Herz-Lungen-Präparat als Modell für die Optimierung von kernspintomographischen Meßsequenzen für das Lungenparenchym.Fortschr Röntgenstr 157: 316.

    Google Scholar 

  11. Frank J et al. (1980) First experiences with a totally mobile artificial heart system.Trans Am Soc Artif Int Organ 26: 72–76.

    CAS  Google Scholar 

  12. Oppelt A, Graumann R, Barfuß H, Fischer H, Hartl W, Schajor W (1986) FISP: eine neue schnelle Pulssequenz für die Kernspintomographie.Electromedica 54: 15–18

    Google Scholar 

  13. van Hecke P, Marchal G, Bosmans H, Johannik K, Vogler H, van Ongeval C, Baert AL, Speck U (1991) NMR imaging study of the pharmacodynamics of polylysinegadolinium-DTPA in the rabbit and the rat.Magn Reson Imaging 9: 313–321.

    Article  PubMed  Google Scholar 

  14. Berthezène Y, Vexler V, Price DC, Wisner-Dupon J, Moseley ME, Aicher KP, Brasch RC (1992) Magnetic resonance imaging detection of an experimental pulmonary perfusion deficit using a macromolecular contrast agent polylysine-gadolinium-DTPA40.Invest Radiol 27: 346–351.

    Article  PubMed  Google Scholar 

  15. Rawson RA (1942) The binding of T-1824 and structurally related diazo dyes by the plasma proteins.Am J Physiol 138: 708–717.

    Google Scholar 

  16. Hansen P, Nielsen NC (1964) The binding of Evans blue to plasma proteins.Scand J Clin Lab Invest 16: 491–497.

    PubMed  CAS  Google Scholar 

  17. Freedman FB, Johnson JA (1969) Equilibrium, kinetic properties of the Evans blue-albumine system.Am J Physiol 216: 675–681.

    PubMed  CAS  Google Scholar 

  18. Pearce ML, Yamashita J, Beazelt J (1965) Measurement of pulmonary edema.Circ Res 5: 482–488.

    Google Scholar 

  19. Julien M, Flick MR, Hoeffel JM, Murray JF (1984) Accurate reference measurement for postmortem lung water.J Appl Physiol 56: 248–253.

    PubMed  CAS  Google Scholar 

  20. Böck JC, Pison U, Kaufmann F, Felix R (1994) Gadolinium-DTPA-polylysine enhanced pulmonary time-offlight angiography.J Magn Reson Imaging 4: 473–476.

    Article  PubMed  Google Scholar 

  21. Kolem H, Goodrich KC, Ganesan K, Ailion DC, Cutillo AG, Chen S, Morris AH, Shioya S, Watanabe S (1989) Spin-spin relaxation in lung: Hahn-echo and Carr-Purcell measurements at different frequencies. InProceedings of the Annual Meeting of the Society of Magnetic Resonance in Medicine, p. 783.

  22. Kveder M, Zupancic I, Lahajnar G, Blinc R, Suput D, Ailion DC, Ganesan K, Goodrich C (1988) Water proton NMR relaxation mechanisms in lung tissue.Magn Reson Med 7: 432–441.

    Article  PubMed  CAS  Google Scholar 

  23. Shioya S, Haida M, Ono Y, Fukuzaki M, Yamabayashi H (1988) Lung cancer: differentiation of tumor, necrosis, and atelectasis by means of T1 and T2 values measuredin vitro.Radiology 167: 105–109.

    PubMed  CAS  Google Scholar 

  24. Shioya S, Haida M, Tsuji C, Ohta Y, Yamabayashi H, Fukuzaki M, Kimula Y (1988) Acute and repair stage characteristics of magnetic resonance relaxation times in oxygen-induced pulmonary edema.Magn Reson Med 8: 450–459.

    Article  PubMed  CAS  Google Scholar 

  25. Shioya S, Kolem H, Ailion DC, Goodrich KC, Cutillo AG, Morris AH, Durney CH (1992) Comparison ofin vivo andin vitro Hahn T2 measurements in rat lungs.Magn Reson Med 26: 1–6.

    Article  PubMed  CAS  Google Scholar 

  26. Shioya S, Christman R, Ailion DC, Cutillo AG, Goodrich KC (1993) Nuclear magnetic resonance Hahn spin-echo decay (T2) in live rats with endotoxin lung injury.Magn Reson Med 29: 441–445.

    Article  PubMed  CAS  Google Scholar 

  27. Fenrich FRE, Allen PS (1992) A simulation evaluation of a linear inverse technique for determining continuous relaxation time distributions. InProceedings of the Annual Meeting of the Society of Magnetic Resonance in Medicine, p. 1309.

  28. Lauterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance.Nature 242: 190–191.

    Article  CAS  Google Scholar 

  29. Bergin CJ, Pauly JM, Macovski A (1991) Lung parenchyma: projection reconstruction MR imaging.Radiology 179: 177–781.

    Google Scholar 

  30. Jackson JI, Nishimura DG, Pauly JM (1992) Twisting radial lines with application to robust magnetic resonance imaging of irregular flow.Magn Reson Med 25: 128–139.

    Article  PubMed  CAS  Google Scholar 

  31. Yudilevich E, Stark H (1987) Spiral sampling in magnetic resonance imaging—the effects of inhomogeneities.IEEE Trans Med Imaging MI 6: 337–345.

    Article  CAS  Google Scholar 

  32. Noll DC, Pauly JM, Meyer CH, Nishimura DG, Macovski A (1992) Deblurring for non-2D Fourier transform magnetic resonance imaging.Magn Reson Med 25: 319–333.

    Article  PubMed  CAS  Google Scholar 

  33. Bergin CJ, Noll DC, Pauly JM, Glover GH, Macovski A (1992) MRI of lung parenchyma: a solution to susceptibility.Radiology 183: 673–676.

    PubMed  CAS  Google Scholar 

  34. Schuhmann-Gampieri G, Schmitt-Willich H, Frenzel T, Press WR, Weinmann HJ (1991)In vivo andin vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging.Invest Radiol 26: 969–974.

    Article  Google Scholar 

  35. Hatabu H, Alsop DC, Listerud J, Bonnet M, Gefter WB (1994) MR imaging and T2 * measurement in lung parenchyma with a submillisecond TE GRE sequence.Radiology 193: 147.

    Google Scholar 

  36. Alsop DC, Hatabu H, Bonnet M, Listerud J, Gefter W (1995) Multi-slice, breathhold imaging of the lung with submillisecond echo times.Magn Reson Med 33: 678–682.

    Article  PubMed  CAS  Google Scholar 

  37. Noll DC, Nishimura DG, Macovski A (1991) Homodyne detection in magnetic resonance imaging.IEEE Trans Med Imaging 10: 154–163.

    Article  PubMed  CAS  Google Scholar 

  38. Felmlee JP, Ehman RL (1987) Spatial presaturation: a method for suppressing flow artifacts and improving depiction of vascular anatomy in MR imaging.Radiology 164: 559–564.

    PubMed  CAS  Google Scholar 

  39. Edelman RR, Atkinson DJ, Silver MS, Loaiza FL, Warren WS (1988) FRODO pulse sequences: a new means of eliminating motion, flow, and wraparound artifacts.Radiology 166: 231–236.

    PubMed  CAS  Google Scholar 

  40. Ehman RL, McNamara MT, Brasch RC, Felmlee JF, Gray JE, Higgins CB (1986) Influence of physiologic motion on the appearance of tissue in MR.Radiology 159: 777–782.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany

    J. Lehmann, J. C. Böck, P. Podrabsky, W. Wlodarczyk & R. Felix

Authors
  1. J. Lehmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Böck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Podrabsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. Wlodarczyk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Felix
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lehmann, J., Böck, J.C., Podrabsky, P. et al. Young Investigator Award Presentation at the 13th Annual Meeting of the ESMRMB, September 1996, Prague Quantification of pulmonary water compartments by magnetic resonance. MAGMA 5, 3–11 (1997). https://doi.org/10.1007/BF02592259

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02592259

Keywords

Search

Navigation