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Prediction of pathological tumor volume in clinically localized prostate cancer: value of endorectal coil magnetic resonance imaging

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Abstract

The purpose of this study was to determine whether endorectal coil magnetic resonance imaging (MRI) enables accurate assessment of pathologic tumor volume in patients with clinically localized prostate carcinoma. Twenty-four patients with biopsy-proved prostate carcinoma underwent MRI at 0.5 T before radical prostatectomy. Tumor volumes were determined independently on axial fast-spin-echo (SE) T2-weighted MR images and whole-mount pathology slides of the surgical specimens. At pathology, tumor volumes ranged from 0.17 to 9.42 cm3 (mean±SD, 3.11±2.99 cm3). A strong correlation (r=.944) was found between measurements of tumor volume based on MR images and pathological specimens. The error was less than 0.5 cm3 in 14 cases, in the range of 0.5–1 cm3 in 7 cases, and more than 1 cm3 in 3 cases. By using an MR tumor volume of 2 cm3 as cutoff value, extracapsular tumor spread could be predicted with a sensitivity of 81.2%, a specificity of 100%, and an accuracy of 87.5%. Tumor volume determinations based on MR images seem to be accurate enough to be helpful in clinical decision-making.

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Authors and Affiliations

  1. Department of Oncology, Division of Radiology, University of Pisa, Via Roma 67, I-56125, Pisa, Italy

    Riccardo Lencioni, Alessandro Paolicchi & Carlo Bartolozzi

  2. IPR Radiological Center, Prato, Italy

    Ilario Menchi

  3. Division of Urology, University of Florence, Florence, Italy

    Marco Carini

  4. Department of Pathology, University of Florence, Florence, Italy

    Andrea Amorosi

Authors
  1. Riccardo Lencioni
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  2. Ilario Menchi
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  3. Alessandro Paolicchi
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  4. Marco Carini
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  5. Andrea Amorosi
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  6. Carlo Bartolozzi
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Lencioni, R., Menchi, I., Paolicchi, A. et al. Prediction of pathological tumor volume in clinically localized prostate cancer: value of endorectal coil magnetic resonance imaging. MAGMA 5, 117–121 (1997). https://doi.org/10.1007/BF02592242

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  • DOI: https://doi.org/10.1007/BF02592242

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