Summary
Twenty-four T cell clones (TCC) specific for purifiedDermatophagoides pteronyssinus group I allergen (Der pI) were established from the peripheral blood of a patient with severe atopic disease and assessed for cytokine production in response to stimulation with both phorbol 12-myristate 13-acetate and anti-CD3 monoclonal antibody. All Der pI-specific TCC produced high amounts of interleukin (IL)-4 in association with IL-3, IL-5 and granulocyte monocyte-colony stimulating factor (GM-CSF), whereas they produced variable amounts of IL-2 and virtually no interferon-γ. These data support the hypothesis that atopy is associated with preferential activation of type 2 T helper cells and suggest a deregulation in the function of the IL-3, IL-4, IL-5 and GM-CSF gene cluster in subjects with severe atopic disorders.
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Parronchi, P., Manetti, R., Simonelli, C. et al. Cytokine production by allergen (Der pI)-specific CD4+ T cell clones derived from a patient with severe atopic disease. Int J Clin Lab Res 21, 186–189 (1992). https://doi.org/10.1007/BF02591641
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DOI: https://doi.org/10.1007/BF02591641