Abstract
On-resonance radio frequency pulse sequences for magnetization transfer are optimized using a frequency domain approach. The method presented here was developed using binomial pulses and it is demonstrated that a simple analysis leads to accurate sequence parameters that can be used directly for magnetic resonance imaging. With thus optimized parameters it is possible to produce an efficient saturation of protons having short transverse relaxation time while protons with long transverse relaxation time are kept nearly unaffected by the radio frequency. The method is particularly well suited to the design of new magnetization transfer sequences and to the estimation of the limits of the accuracy of aT 2 selection. Additionally in vitro tests have been performed on beef tendon oriented with a zero fiber to field angle.
Similar content being viewed by others
References
Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10:135.
Henkelmann RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993;29:759.
Koenig SH, Brown RD, Ugloni R. Magnetization transfer in cross-linked bovine serum albumin solutions at 200 MHz: A model for tissue. Magn Reson Med 1993;29:311.
Pachot Clouard M. Transfert d'aimantation: Optimisation, extraction des paramètres de l'échange et IRMchez l'homme et l'animal. Thèse. Université Paris Sud, Orsay, 1996.
Hu BS, Conolly SM, Wright GA, Nishimura DG, Macovski A. Pulsed saturation transfer contrast. Magn Reson Med 1992;26:231.
Hore PJ. Solvent suppression in Fourier transform nuclear magnetic resonance. J Magn Reson 1983;55:283.
Pike CB. Pulsed magnetization transfer spin-echo MR imaging. J Magn Reson Imag 1993;3:531.
Baguet E. Renouvellement de l'ATP dans la cellule vegetale: Methodologie du transfert de saturation en RMN31P Thèse Université Joseph Fourier, Grenoble, 1992.
Morris GA, Freeman R. Selective excitation in Fourier transform nuclear magnetic resonance. J Magn Reson 1978;29:433.
Bauer C, Freeman R, Frenkiel T, Keeler J, Shaka AJ. Gaussian pulses. J Magn Reson 1984;58:442.
Van Vleck JH. The dipolar broadening of magnetic resonance lines in crystals. Phys Rev 1948;74(9):1168.
Bloembergen N. Nuclear magnetic relaxation. New York: Benjamin, 1961.
Morrison C, Enkelmann RM. A model for magnetization transfer in tissues. Magn Reson Med 1995;23:475.
Hore PJ. A new method for water suppression in the proton NMR spectra of aqueous solutions. J Magn Reson 1983;54:539.
Pachot-Clouard M, Darasse L. Optimization ofT 2-selective binomial pulses for magnetization transfer. Magn Reson Med 1995;34:462.
Heywood HB, Frechet M. L'équation de Fredholm et ses applications à la physique mathématique. Paris: Hermann, 1912.
Eggermont PPB. Maximum entropy regularization for Fredholm integral equations of the first kind. SIAM J Math Anal 1993;24:1557.
Forster J, Schick F, Pfeffer M, Lutz O. Magnetization transfer by simple sequences of rectangular pulses. MAGMA 1995;3:83.
Fullerton GD, Cameron IL, Ord VA. Orientation of tendons in the magnetic field and its effect onT 2 relaxation times. Radiology 1985;155:433.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Grenier, D., Deval, S. & Briguet, A. A new approach for on-resonance magnetization transfer parameter optimization. MAGMA 7, 131–140 (1998). https://doi.org/10.1007/BF02591330
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02591330