Skip to main content

Advertisement

SpringerLink
Log in

Carcinoembryonic antigen in colorectal practice: Report of three cases

  • Published:
Diseases of the Colon & Rectum

Summary

CEA, in combination with the time-honored barium enema, sigmoidoscopy, rectal examination with guaiac determinations, and thorough clinical history, is a useful tool for the colorectal surgeon in following the progression of disease in both colorectal carcinoma patients and patients who have certain premalignant conditions. In this high-risk group of patients, CEA determinations as well as colonoscopy are becoming increasingly useful. That tumors on the left side are associated with higher CEA levels than those on the right, side, due to vascular invasion or the grades of the tumors, and that often CEA antigenicity and severity of symptoms in ulcerative colitis correlate well, are emphasized. Finally, following total colectomy in five cases of ulcerative colitis, all CEA titers decreased to the normal range and have remained there.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Chapter © 2017

References

  1. Bivins BA, Meeker WR Jr, Pellegrini J, et al: Carcinoembryonic antigen levels and tumor histology in colon cancer. J Surg Res 18: 257–261, 1975

    Article  PubMed  CAS  Google Scholar 

  2. Burtin P: Membrane antigens of the colonic tumors. Cancer 34: 829, 1974

    Article  PubMed  CAS  Google Scholar 

  3. Burtin P, Chavanel G: A new and fast method of preparation of CEA. Ann Immunol (Paris) (in press)

  4. Chu TM, Nemoto T: Evaluation of carcinoembryonic antigen in human mammary carcinoma. J Natl Cancer Inst 51: 1119, 1973

    PubMed  CAS  Google Scholar 

  5. Concannon JP, Dalbow MH, Liebler GA, et al: The carcinoembryonic antigen assay in bronchogenic carcinoma. Cancer 34: 184, 1974

    Article  PubMed  CAS  Google Scholar 

  6. Edynak EM, Old IJ, Vrana M, et al: A fetal antigen in human tumors detected by an antibody in the serum of cancer patients (abstr). Proc Am Assoc Cancer Res 11: 22, 1970

    Google Scholar 

  7. Egan ML, Coligan JE, Todd CW: Radio-immune assay for the diagnosis of human cancer. Cancer 34: 1504, 1974

    Article  PubMed  CAS  Google Scholar 

  8. Fleisher M, Oettgen HF, Breed CN, et al: CEA-like material in fluid from benign cysts of the breast. Clin Chem 20: 41, 1974

    PubMed  CAS  Google Scholar 

  9. Gold P, Freedman SO: Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 121: 439, 1965

    Article  PubMed  CAS  Google Scholar 

  10. Guinan P, Ablin R, Sadöughi N, et al: Carcinoembryonic-like antigen in the urine of patients with carcinoma of the bladder and normal controls. J Surg Oncol 6: 127, 1974

    Article  PubMed  CAS  Google Scholar 

  11. Hansen HJ, Snyder JJ, Miller E, et al: Carcinoembryonic Antigen (CEA) Assay: A Laboratory Adjunct in the Diagnosis and Management of Cancer. Hoffman-LaRoche, Inc., Nutley, N. J., Nov. 27, 1973

    Google Scholar 

  12. Joint National Cancer Institutes of Canada/ American Cancer Society Investigation: A collaborative study of a test for carcino-embryonic antigen (CEA) in the sera of patients with carcinoma of the colon and rectum. Can Med Assoc J 107: 25, 1972

    Google Scholar 

  13. Khoo SK, Mackay EV: Carcinoembryonic antigen in cancer of the female reproductive system: Its detection in serum by a microradioimmunoassay. Aust NZ J Obstet Gynaecol 13: 107, 1973

    CAS  Google Scholar 

  14. von Kleist S, Burtin P: Localisation cellulaire d'un antigène embryonnaire de tumeurs coliques humaines. Int J Cancer 4: 874, 1969

    Article  Google Scholar 

  15. Livingstone AS, Hampson LG, Shuster J, et al: Carcinoembryonic antigen in the diagnosis and management of colorectal carcinoma: Current status. Arch Surg 109: 259, 1974

    PubMed  CAS  Google Scholar 

  16. Lo Gerfo P, Krupey J, Hansen HJ: Demonstration of a common neoplastic antigen (abstr). Clin Res 19: 143, 1971

    Google Scholar 

  17. Lo Gerfo P, Lo Gerfo F, Herter F, et al: Tumor-associated antigen in patients with carcinoma of the colon. Am J Surg 123: 127, 1972

    Article  PubMed  Google Scholar 

  18. Martin EW Jr, Kibbey WE, Minton JP: Learning more about CEA. Ohio State Med J 71: May 1975

  19. Martin EW Jr, Kibbey WE, Minton JP, et al: Carcinoembryonic antigen, clinical and historical aspects. Cancer 37: 62–81, 1976

    Article  PubMed  Google Scholar 

  20. Martin EW Jr, Skivolocki W, Minton JP, et al: Carcinoembryonic antigen as an adjunct in the diagnosis and prognosis of colorectal carcinoma. Rev Surg 32: 214–217, 1975

    PubMed  CAS  Google Scholar 

  21. Meeker WR Jr, Kashmiri R, Hunter L, et al: Clinical evaluation of carcinoembryonic antigen test. Arch Surg 107: 266, 1973

    PubMed  Google Scholar 

  22. Moore TL, Dhar P, Zamcheck N, et al: Carcinoembryonic antigen(s) in liver disease. I. Clinical and morphological studies. Gastroenterology 63: 88, 1972

    PubMed  CAS  Google Scholar 

  23. Moore TL, Kupchick HZ, Marcon N, et al: Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis 16: 1, 1971

    Article  PubMed  CAS  Google Scholar 

  24. Moore TL, Kupchick H, Marcon N, et al: Carcinoembryonic antigen (CEA) in the evaluation of gastrointestinal malignancy (abstr). Clin Res 18: 680, 1970

    Google Scholar 

  25. Morson BC: Evolution of cancer of the colon and rectum. Cancer 34: 845, 1974

    Article  PubMed  Google Scholar 

  26. Morson BC: Cancer in ulcerative colitis. Gut 7: 425, 1966

    PubMed  CAS  Google Scholar 

  27. Morson BC, Pang LS: Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 8: 423, 1967

    PubMed  CAS  Google Scholar 

  28. Ona FV, Zamcheck N, Dhar P, et al: Carcinoembryonic antigen in the diagnosis of pancreatic cancer. Cancer 31: 324, 1973

    Article  PubMed  CAS  Google Scholar 

  29. Rule AH, Sachar D, Goleski Reilly C, et al: Circulating carcinoembryonic antigen (CEA): Relationship to clinical status of patients with inflammatory bowel disease (abstr). Gastroenterology 64: 794, 1973

    Google Scholar 

  30. Second Conference, CEA Test Collaborative Study. Hoffmann-LaRoche, Inc., Nutley, N. J., Apr. 21, 1972

  31. Skarin A, Delwiche R, Zamcheck N, et al: Carcinoembryonic antigen (CEA): Correlation with chemotherapy for metastatic gastro-intestinal (GI) cancer (abstr). Clin Res 21: 983, 1973

    Google Scholar 

  32. Skarin AT, Delwiche R, Zamcheck N, et al: Carcinoembryonic antigen: Clinical correlation with chemotherapy for metastatic gastro-intestinal cancer. Cancer 33: 1239, 1974

    Article  PubMed  CAS  Google Scholar 

  33. Sorokin J, Sugarbaker P, Zamcheck N, et al: Serial carcinoembryonic antigen assays: Use in detection of cancer recurrence. JAMA 228: 49, 1974

    Article  PubMed  CAS  Google Scholar 

  34. Steward AM, Nixon D, Zamcheck N, et al: Carcinoembryonic antigen in breast cancer patients: Serum levels and disease progress. Cancer 33: 1246, 1974

    Article  PubMed  CAS  Google Scholar 

  35. Steward AM, Nixon DW, Zamcheck N, et al: Serum carcinoembryonic antigen (CEA) levels in breast cancer patients: Correlation with disease progress and response to chemotherapy (abstr). Clin Res 21: 983, 1973

    Google Scholar 

  36. Thomson DM, Krupey J, Freedman SO, et al: The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci USA 64: 161, 1969

    Article  PubMed  CAS  Google Scholar 

  37. Watson DW: Ulcerative colitis, autoimmune epiphenomena, and colonic cancer. Cancer 34: 867, 1974

    Article  PubMed  Google Scholar 

  38. Watson DW, Martucci R: Inhibition of peripheral leucocyte migration byE. coli 0119: B14 antigen in normal individuals and patients with chronic inflammatory bowel disease (CIBD) (abstr). Gastroenterology 64: 818, 1973

    Google Scholar 

  39. Watson DW, Quigley A, Bolt RJ: Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells. Gastroenterology 51: 985, 1966

    PubMed  CAS  Google Scholar 

  40. Wolff WI, Shinya H: Earlier diagnosis of cancer of the colon through colonic endoscopy (colonoscopy). Cancer 34: 912, 1974

    Article  PubMed  Google Scholar 

  41. Wolff WI, Shinya H: Polypectomy via fiberoptic colonoscope: Removal of neoplasms beyond reach of sigmoidoscope. Yearbook of Surgery, 1974, p 422

  42. Xavier RG, Prolla JC, Bemvenuti GA, et al: Tissue cytogenetic studies in chronic ulcerative colitis and carcinoma of the colon. Cancer 34: 684, 1974

    Article  Google Scholar 

  43. Yardley JH, Keren DF: “Precancer” lesions in ulcerative colitis: A retrospective study of rectal biopsy and colectomy specimens. Cancer 34: 835, 1974

    Article  PubMed  Google Scholar 

  44. Zamcheck N, Moore TL, Dhar P, et al: Immunologic diagnosis and prognosis of human digestive-tract cancer: Carcinoembryonic antigens. N Engl J Med 286: 83, 1972

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, The Ohio State University College of Medicine, 410 West Tenth Avenue, 43210, Columbus, Ohio

    Edward W. Martin Jr. M.D., William E. Kibbey M.D., Ralph Samson M.D., William Stewart M.D., Thomas Hardy M.D. & John P. Minton M.D., Ph.D.

Authors
  1. Edward W. Martin Jr. M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William E. Kibbey M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ralph Samson M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. William Stewart M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Thomas Hardy M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. John P. Minton M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Read at the Meeting of the American Society of Colon and Rectal Surgeons, San Francisco, California, May 4 to 8, 1975.

Supported in part by Hoffmann-LaRoche, Inc., Phi Beta Psi, and the Ohio Chapter of the Eastern Star.

About this article

Cite this article

Martin, E.W., Kibbey, W.E., Samson, R. et al. Carcinoembryonic antigen in colorectal practice: Report of three cases. Dis Colon Rectum 19, 99–106 (1976). https://doi.org/10.1007/BF02590859

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02590859

Keywords

Search

Navigation