Serum glucose concentrations of 112 blood samples determined by the GOD/POD/Trinder method were compared with values obtained on whole blood by means of the Glucometer reflectance meter and two different reagent strips, Dextrostix and an experimental strip (GX 947822), in order to establish over a wide range of glucose concentrations, the precision and reproducibility of reflectometric methods. The two methods examined showed an excellent correlation with the reference method, particularly if data were corrected for the individual hematocrit value, and both accuracy and precision were reasonably satisfactory.