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Der Einfluß von Cyclophosphamid auf die Knochenbruchheilung am Kaninchenfemur

The influence of cyclophosphamide upon the healing of fractures in the rabbit

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Zusammenfassung

Es wird über den Einfluß von Cyclophosphamid (Ctx) auf die Knochenbruchheilung des Kaninchenfemurs berichtet. Röntgenologisch zeigte sich unter Gabe von Ctx eine verminderte Kallusbildung, was sich fluoreszenzmikoskopisch in der verringerten Knochenanbaurate darstellte. Während Bruchlast, Bruchenergie und Mineralsalzgehalt am nichtoperierten Knochen durch die Behandlung mit Ctx keine Änderung erfuhr, sank die Bruchlast und die Bruchenergie 4 Wochen post operationem um nahezu um die Hälfte, und der Mineralsalzgehalt war signifikant herabgesetzt.

Abstract

The influence of cyclophosphamide (Ctx) upon the healing of fractures in the femur of the rabbit is reported. During treatment with Ctx the x-ray shows a reduced callus-formation; the fluorescence-microscopy reveals a decreased appostition of bone. Fracture-load, fracture-energy and mineral content of the intact bone are not influenced by Ctx. Four weeks after an operation fracture-load and fracture-energy are reduced almost by one half and the mineral content is decreased significantly.

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Authors and Affiliations

  1. Abteilung für Unfallchirurgie, Germany

    H. -U. Langendorff, H. -D. Sauer, H. Schöttle, J. -D. Ringe & K. -H. Jungbluth

  2. Abteilung für Klinische Osteologie, Germany

    H. -U. Langendorff, H. -D. Sauer, H. Schöttle, J. -D. Ringe & K. -H. Jungbluth

  3. Universitäts-Krankenhauses Hamburg-Eppendorf, Germany

    H. -U. Langendorff, H. -D. Sauer, H. Schöttle, J. -D. Ringe & K. -H. Jungbluth

  4. Direktor der Unfallchirurgischen Univ.-Klinik, Martinistr. 52, D-2000, Hamburg-Eppendorf

    K. -H. Jungbluth

Authors
  1. H. -U. Langendorff
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  2. H. -D. Sauer
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  3. H. Schöttle
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  4. J. -D. Ringe
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  5. K. -H. Jungbluth
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Langendorff, H.U., Sauer, H.D., Schöttle, H. et al. Der Einfluß von Cyclophosphamid auf die Knochenbruchheilung am Kaninchenfemur. Unfallchirurgie 7, 231–235 (1981). https://doi.org/10.1007/BF02589665

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  • DOI: https://doi.org/10.1007/BF02589665

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