Abstract
A retrospective review of all the 951 patients less than 40 years of age with colorectal cancer in Denmark 1943–67 is described. The annual incidence in Denmark of colorectal cancer in this age group is 1.4/100,000. These patients do not differ from other patients with colorectal cancer with regard to sex ratio, tumor localization, extent of tumor growth, histologic type, frequency of intestinal obstruction and perforation. Of these patients 53 per cent were subjected to radical operation. The five-year crude survival rate was 32 per cent for all patients and 65 per cent in cases of radical operation. The operative mortality was 9 per cent. The extent of tumor growth according to Dukes' classification and the presence of intestinal obstruction and/or perforation were the only factors found to influence the prognosis. The survival rates correspond to rates given in the literature in respect of colorectal cancer, regardless of age. It is concluded that colorectal cancer in young patients differs in no respect from the disease in older patients.
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References
Coffey RJ, Cardenas F. Cancer of the bowel in the young adult. Dis Colon Rectum 1964;7:491–2.
Ezzo JA, Sullivan JF, Mack RE. Carcinoma of the colon under the age of 40. Ann Intern Med 1958;49:321–5.
Simstein NL, Kovalcik PJ, Cross GH. Colorectal carcinoma in patients less than 40 years old. Dis Colon Rectum 1978;21:169–71.
Howard EW, Cavallo C, Hovey LM, Nelson TG. Colon and rectal cancer in the young adult. Am Surg 1975;41:260–5.
Scarpa FJ, Hartmann WH, Sawyers JL. Adenocarcinoma of the colon and rectum in young adults. South Med J 1976;69:24–7.
Postlethwait RW, Adamson JE, Hart D. Carcinoma of the colon and rectum. Surg Gynecol Obstet 1958;106:257–70.
Hall A, Coffey RJ. Cancer of the large bowel in the young adult. Am J Surg 1961;102:66–72.
Sanfelippo PM, Beahrs OH. Carcinoma of the colon in patients under forty years of age. Surg Gynecol Obstet 1974; 138:169–70.
Walton WW Jr, Hagihara PF, Griffen WO Jr. Colorectal adenocarcinoma in patients less than 40 years old. Dis Colon Rectum 1976;19:529–34.
Clemmesen J. Statistical studies in the aetiology of malignant neoplasms. II. Acta Pathol Microbiol Scand 1965;suppl 174 II:2–319.
Clemmesen J. Statistical studies in the aetiology of malignant neoplasms. IV. Acta Pathol Microbiol Scand 1974;suppl 247:9–266.
Svendsen LB, Bülow S. Carcinoid tumors of the appendix in young patients. Acta Chir Scand (in press).
Dukes CE. The classification of cancer of the rectum. J Pathol 1932;35:323–32.
Horwitz O. Vejledning ved prognoseberegninger i DIKE. Danish Institute of Clinical Epidemiology, Copenhagen, 1977.
Statistiske meddelelser 1978. 12: 72. Befolkningens bevagelser 1977. Danmarks Statistik, Copenhagen, 1978.
Steiner J. Areolan Krebs des Dickdarms bei einem neunjahrigen Knaben. Jahrb Kinderh 1865;7:61–4.
Recalde M, Holyoke ED, Elias EG. Carcinoma of the colon, rectum, and anal canal in young patients. Surg Gynecol Obstet 1974;139:909–13.
Grinnell RS. Results in the treatment of carcinoma of the colon and rectum: an analysis of 2,341 cases over a 35 year period with 5 year survival results in 1,667 patients. Surg Gynecol Obstet 1953;96:31–42.
Alarcon J, Greenwood GR. Adenocarcinoma of the colon and rectum: a review of surgical treatment in 302 patients. Dis Colon Rectum 1979;22:35–9.
Berge T, Ekelund G, Mellner C, Pihl B, Wenckert A. Carcinoma of the colon and rectum in a defined population: an epidemiological, clinical and postmortem investigation of colorectal carcinoma and coexisting benign polyps in Malmö, Sweden. Acta Chir Scand 1973;suppl 438:9–86.
Floyd CE, Stirling CT, Cohn I Jr. Cancer of the colon, rectum and anus: review of 1,687 cases. Ann Surg 1966;163:829–37.
Welch JP, Donaldson GA. Recent experience in the management of cancer of the colon and rectum. Am J Surg 1974;127:258–66.
Bockus HL, ed. Gastroenterology. 3rd ed. Philadelphia: WB Saunders, 1976: Vol. 2.
Rhoads JE, Allen JG, Harkins HN, Moyer CA. Surgery: principles and practice. 4th ed. Philadelphia: JB Lippincott, 1970.
Smiddy FG, Goligher JC. Results of surgery in treatment of cancer of the large intestine. Br Med J 1957;1:793–6.
Devitt JE, Roth-Moyo LA, Brown FN. The significance of multiple adenocarcinomas of the colon and rectum. Ann Surg 1969;169:364–7.
Gilbertsen VA. Adenocarcinoma of the large bowel: 1,340 cases with 100 per cent follow-up. Surgery 1959;46:1027–42.
Goligher JC. Surgery of the anus, rectum and colon. London: Cassell, 1961.
Floyd CE, Cohn I Jr. Obstruction in cancer of the colon. Ann Surg 1967;165:721–31.
Crowder VH Jr, Cohn I Jr. Perforation in cancer of the colon and rectum. Dis Colon Rectum 1967;10:415–20.
Corman ML, Swinton NW, O'Keefe DD, Veidenheimer MC. Colorectal carcinoma at the Lahey Clinic, 1962 to 1966. Am J Surg 1973;125:424–8.
Gilbertsen VA. Results of treatment of bowel cancer. Ann Surg 1963;157:198–203.
Bussey HJR, Wallace MH, Morson BC. Metachronous carcinoma of the large intestine and intestinal polyps. Proc R Soc Med 1967;60:208–10.
Moertel CG, Bargen JA, Dockerty MB. Multiple carcinomas of the large intestine: a review of the literature and a study of 261 cases. Gastroenterology 1958;34:85–98.
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Bülow, S. Colorectal cancer in patients less than 40 years of age in Denmark, 1943–1967. Dis Colon Rectum 23, 327–336 (1980). https://doi.org/10.1007/BF02586840
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DOI: https://doi.org/10.1007/BF02586840