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Haemorrheology of equine platelet-neutrophil aggregates

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Abstract

The filterability of platelet-neutrophil aggregates through filters containing 5 μm pores was determined to evaluate the potential of plateletneutrophil aggregates to alter blood flow in the microvasculature. Incubation of platelet-neutrophil mixture with platelet-activating factor (PAF) and with 0.5 μM adenosine diphosphate (ADP) resulted in large platelet-neutrophil aggregates which rapidly plugged filter pores. Incubation of platelet-neutrophil mixtures with lower concentrations of ADP resulted in small platelet-neutrophil aggregates that contained only one neutrophil. Filtration of these samples resulted in a 1.3-, 3.2- and 3.7-fold increase in initial filtration pressure at ADP concentrations of 0.05, 0.15 and 0.25 μM, respectively. We conclude that platelet-neutrophil aggregates have reduced deformability and may alter blood flow in the microvasculature.

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Authors and Affiliations

  1. Department of Veterinary PathoBiology, University of Minnesota, 55108, St Paul, MN, USA

    D. J. Weiss, O. A. Evanson, D. McClenahan & J. J. Fagliari

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  1. D. J. Weiss
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  2. O. A. Evanson
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  3. D. McClenahan
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  4. J. J. Fagliari
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Weiss, D.J., Evanson, O.A., McClenahan, D. et al. Haemorrheology of equine platelet-neutrophil aggregates. Comp Haematol Int 9, 55–59 (1999). https://doi.org/10.1007/BF02585536

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