Abstract
In a previous paper, the theoretical development of several advanced nonlinear models of equivalent cardiac generators was presented. The present communication compares the salient quantitative and qualitative aspects of these models in an idealized mathematical environment.
Using physiologically realistic simulated data, we have tested a single moving dipole, two moving dipoles, a moving dipole and quadripole, and a truncated spherical multipole expansion both for their ability to reproduce surface potential distributions and to be resolved in an inverse sense.
Results are presented which indicate that, in general, a minimum of 32 observation points are necessary to resolve these models for the given spherically bounded system. In addition, a single moving dipole is not capable of reproducing the multimaxima-multiminima potential distributions characteristic of the simulated data. Although the other models are capable of mimicking spherical surface potential distributions, considerable computational effort is required to realize these inverse solutions.
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This research was supported by Grants HL-01362, HL-14032, and HL-09495 of the National Heart and Lung Institute, National Institutes of Health, U. S. Public Health Service.
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Martin, R.O., Keller, F.W., Cox, J.W. et al. A comparative study of nonlinear equivalent cardiac generators. Ann Biomed Eng 3, 47–61 (1975). https://doi.org/10.1007/BF02584488
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DOI: https://doi.org/10.1007/BF02584488