Summary
Carbohydrate metabolism and insulin secretion in acromegaly have been studied by means of simulation and analogue analysis of plasma insulin and blood glucose curves obtained during OGTT in 20 acromegalic patients, using a model planned in our laboratory. Patients were arbitrarily subdivided into three groups according to blood glucose level at 120 min. Patients (8) with blood glucose level below or equal to 140 mg/100 ml were assigned to the first group; those (8) with blood glucose level ranging from 140 to 200 mg/100 ml were assigned to the second group; the remaining 4 patients with blood glucose level exceeding 200 mg/100 ml were assigned to the third group. Analogue simulation has shown that: 1) hepatic glycogenolysis is decreased in all patients; 2) peripheral glucose utilization is also decreased in all patients; 3) in the first group of patients, B-cell responsiveness to glucose and to gut hormones is increased; 4) in the second group, B-cell responsiveness to glucose is increased, whereas responsiveness to gut hormones is unchanged; 5) in the third group, B-cells still respond well to blood glucose variations but are not capable of reacting to high glycemic levels if these are constant; B-cell responsiveness to gut hormones remains normal; 6) insulin disappearance rate for biological purposes is decreased in all patients.
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This study was supported by C.N.R. grant: reference n. 72.00636.04.
Istituto di Biologia Animale dell’Università di Padova.
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Scandellari, C., Casara, D., Zaccaria, M. et al. Analogue analysis of oral glucose tolerance test and insulin secretion in acromegaly. Acta diabet. lat 11, 61–70 (1974). https://doi.org/10.1007/BF02581940
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DOI: https://doi.org/10.1007/BF02581940