Skip to main content
SpringerLink
Log in

Calcium homeostasis in prepubertal diabetic children

  • Original Contributions
  • Published:
Acta diabetologia latina Aims and scope Submit manuscript

Summary

Many authors have described abnormalities of calcium homeostasis in type I diabetes mellitus, but data in the literature are conflicting. Consequently we studied calcium, phosphorus and magnesium (in serum and urine), parathyroid hormone, calcitonin and 25-hydroxyvitamin D (25-OHD) levels in 21 prepubertal diabetic patients and in 21 sex- and age-matched controls. We did not find any significant difference of all the aforementioned parameters between diabetics and controls. Also the value of 25-OHD was similar in diabetic and healthy subjects (24.33 ± 6.04vs 22.09 ± 5.01 ng/ml). The results suggest that the principal parameters of calcium metabolism are normal in prepubertal diabetic children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aksnes L., Aarskog D.: Plasma concentrations of vitamin D metabolites in puberty: effect of sexual maturation and implications for growth — J. clin. Endocrinol. Metabol.55, 94, 1982.

    CAS  Google Scholar 

  2. Bank N.: Multiple abnormalities of calcium metabolites in insulin dependent diabetes. Possible relationship to microvascular disease — J. clin. Hypertens.3, 295, 1986.

    Google Scholar 

  3. Christiansen C., Christiansen M. S., McNair P., Nielsen B., Madsbad S.: Vitamin D metabolites in diabetic patients: decreased serum concentrations of 24,25-dihydroxyvitamin D — Scand. J. clin. Lab. Invest.42, 487, 1982.

    Article  PubMed  CAS  Google Scholar 

  4. Frazer T. E., White N. H., Hough S., Santiago J. V., McGee B. R., Bryce G., Mallon J., Avioli L. V.: Alterations in circulating vitamin D metabolites in the young insulin-dependent diabetic — J. clin. Endocrinol. Metabol.53, 1154, 1981.

    CAS  Google Scholar 

  5. Gertner J. M., Tamborlane W. V., Horst R. L., Sherwin R. S., Felig P., Genel M.: Mineral metabolism in diabetes mellitus: changes accompanying treatment with a portable subcutaneous insulin infusion system — J. clin. Endocrinol. Metabol.50, 862, 1980.

    CAS  Google Scholar 

  6. Heath H., Lambert P. W., Service F. J., Arnand S. B.: Calcium homeostasis in diabetes mellitus — J. clin. Endocrinol. Metabol.49, 462, 1979.

    CAS  Google Scholar 

  7. Hui S. L., Epstein S., Johnston C. C.: A prospective study of bone mass in patient with type 1 diabetes — J. clin. Endocrinol. Metabol.60, 74, 1985.

    Article  CAS  Google Scholar 

  8. McNair P., Fogh-Andersen N., Madsbad S., Cristensen M. S.: Decreased serum concentration of ionized calcium in insulin-dependent human diabetes mellitus — Europ. J. clin. Invest.13, 267, 1983.

    Article  PubMed  CAS  Google Scholar 

  9. McNair P., Madsbad S., Christiansen M. S., Christiansen C., Faber O. K., Binder C., Transbøl I.: Bone mineral loss in insulin-treated diabetes mellitus: studies on pathogenesis — Acta endocrinol. (Kbh.)90, 463, 1979.

    CAS  Google Scholar 

  10. McNair P., Madsbad S., Christiansen C., Faber O. K., Transbøl I., Binder C.: Osteopenia in insulin treated diabetes mellitus. Its relation to age at onset, sex and duration of disease — Diabetologia15, 87, 1978.

    Article  PubMed  CAS  Google Scholar 

  11. Nyomba B. L., Bouillon R., Bidingija M., Kandjungu K., De Moor P.: Vitamin D metabolites and their binding protein in adult diabetic patients — Diabetes35, 911, 1986.

    Article  PubMed  CAS  Google Scholar 

  12. Nyomba B. L., Bouillon R., Lissens W., van Baelen H., De Moor P.: 1,25-dihydroxyvitamin D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats — Endocrinology116, 2483, 1985.

    PubMed  CAS  Google Scholar 

  13. Røland O., Markestad T., Aksnes L., Aarskog D.: Plasma concentrations of vitamin D metabolites during puberty of diabetic children — Diabetologia28, 663, 1985.

    Article  Google Scholar 

  14. Rosenbloom A. L.: Skeletal and joint manifestations of childhood diabetes — Pediatr. Clin. N. Amer.31, 569, 1984.

    CAS  Google Scholar 

  15. Ross B. A., Lindall A. W.: Detection and characterization of small midregion parathyroid hormone fragment(s) in normal and hyperparathyoid glands and sera by immunoextraction and region-specific radioimmunoassays — J. clin. Endocrinol. Metabol.53, 709, 1981.

    Google Scholar 

  16. Sjögren A., Florén C. H., Nilsson A.: Magnesium deficiency in IDDM related to level of glycosylated hemoglobin — Diabetes35, 459, 1986.

    Article  PubMed  Google Scholar 

  17. Storum T. L., Sørensen O. H., Lund Bj., Lund Bi., Christiansen J. S., Andersen A. R., Lumhotz I. B., Parving H.-H.: Vitamin D metabolism in insulin dependent diabetes mellitus — Metabol. Bone Dis. relat. Res.5, 107, 1983.

    Article  Google Scholar 

  18. Weber G., Proadella C., Rimoldi R., Proverbio M. C.: Study of calcium homeostasis in children with type I diabetes at the onset. In:Chiumello G., Sperling M. (Eds): Recent progress in pediatric endocrinology, Vol. 4 Raven Press, New York, 1983; p. 61.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinica Pediatrica, Università di Chieti, Chieti, Italy

    Alberto Verrotti, Annalisa Blasetti, Stefano Tumini, Francesco Chiarelli & Guido Morgese

Authors
  1. Alberto Verrotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annalisa Blasetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stefano Tumini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Francesco Chiarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guido Morgese
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verrotti, A., Blasetti, A., Tumini, S. et al. Calcium homeostasis in prepubertal diabetic children. Acta diabet. lat 25, 173–177 (1988). https://doi.org/10.1007/BF02581382

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02581382

Key-words

Search

Navigation