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The effects of muscular exercise on glucose, free fatty acids, alanine and lactate in type I diabetic subjects in relation to metabolic control

Acta diabetologia latina volume 25, pages 155–160 (1988)Cite this article

Summary

Metabolic effects of muscular exercise were studied in eleven subjects with type I diabetes mellitus during poor metabolic control, and again during good metabolic control, and in ten healthy control subjects. All the subjects were submitted to a submaximal gradual triangular test on an electrically braked bicycle ergometer; glucose, FFA, alanine and lactate were measured at rest, and after exercise. In poorly controlled patients, glucose and FFA were unchanged after exercise, whereas blood alanine and lactate increased by a percentage similar to that of the controls, and well-controlled diabetic patients. Baseline alanine concentrations were lower and lactate concentrations higher than in the controls and well-controlled patients. After adequate metabolic control was achieved, in the well-controlled diabetic patients a normalization of pre-exercise alanine and lactate levels and a decrease in blood glucose and FFA after exercise was observed.

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Authors and Affiliations

  1. Istituto di Clinica Medica, Cattedra di Clinica Medica Base, Università degli Studi di Palermo, Palermo, Italy

    Maria Donatelli, Salvatore Verga, Vincenza Russo, Caterina Terrizzi, Maria Luisa Bucalo, Antonina Scarpinato, Maria Vaccaro & Giovanni Cerasola

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  1. Maria Donatelli
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  2. Salvatore Verga
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  3. Vincenza Russo
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  4. Caterina Terrizzi
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  5. Maria Luisa Bucalo
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  6. Antonina Scarpinato
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  7. Maria Vaccaro
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  8. Giovanni Cerasola
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This study was supported by theMinistero della Pubblica Instruzione (60%).

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Donatelli, M., Verga, S., Russo, V. et al. The effects of muscular exercise on glucose, free fatty acids, alanine and lactate in type I diabetic subjects in relation to metabolic control. Acta diabet. lat 25, 155–160 (1988). https://doi.org/10.1007/BF02581380

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  • DOI: https://doi.org/10.1007/BF02581380

Key-words

  • Alanine
  • FFA
  • Glucose
  • Lactate
  • Muscular exercise
  • Type I diabetes mellitus