Metabolic effects of muscular exercise were studied in eleven subjects with type I diabetes mellitus during poor metabolic control, and again during good metabolic control, and in ten healthy control subjects. All the subjects were submitted to a submaximal gradual triangular test on an electrically braked bicycle ergometer; glucose, FFA, alanine and lactate were measured at rest, and after exercise. In poorly controlled patients, glucose and FFA were unchanged after exercise, whereas blood alanine and lactate increased by a percentage similar to that of the controls, and well-controlled diabetic patients. Baseline alanine concentrations were lower and lactate concentrations higher than in the controls and well-controlled patients. After adequate metabolic control was achieved, in the well-controlled diabetic patients a normalization of pre-exercise alanine and lactate levels and a decrease in blood glucose and FFA after exercise was observed.
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Ahlborg G., Felig P., Hagenfeldt L., Hendler R., Wahren J.: Substrate turnover during prolonged exercise in man — J. clin. Invest.53, 1080, 1974.
Balasse E. O.: Inhibition of free fatty acid oxidation by acetoacetate in normal dogs — Europ. J. clin. Invest.1, 155, 1970.
Berger M., Berchtold P., Cüppers H. J., Drost H., Kley H. K., Müller W. A., Wiegelmann W., Zimmermann-Telschow H., Gries F. A., Krüskemper H. L., Zimmermann H.: Metabolic and hormonal effects of muscular exercise in juvenile type diabetics — Diabetologia13, 355, 1977.
Berger M., Kemmer F. W., Goodman M. N., Zimmermann-Telschow H., Ruderman N. B.: Ketone body metabolism in isolated perfused muscle. In:Sorling H. D., Sanfert C. D. (Eds): Biochemical and clinical aspects of ketone body metabolism. Thieme Verlag, New York, 1978; p. 193.
Campaigne B. N., Gilliam T. B., Spencer M. L., Lampman R. M., Schork M. A.: Effects of physical activity program on metabolic control and cardiovascular fitness in children with insulin-dependent diabetes mellitus — Diabet. Care7, 57, 1984.
Felig P., Wahren J.: Amino acid metabolism in exercising man — J. clin. Invest.50, 2703, 1971.
Felig P., Wahren J.: Fuel homeostasis in exercise — New Engl. J. Med.293, 1078, 1975.
Hagenfeldt L.: Metabolism of free fatty acids and ketone bodies during exercise in normal and diabetic man — Diabetes28 (Suppl. 1), 66, 1979.
Klachko D. M., Lie T. H., Cunningham E. J., Chase G. R., Burns T. W.: Blood glucose levels during walking in normal and diabetic subjects — Diabetes21, 89, 1972.
Koivisto V. A., Felig P.: Effects of leg exercise on insulin absorption in diabetic patients — New Engl. J. Med.298, 77, 1978.
Rickter E. A., Rudeman N. B., Schneider S. H.: Diabetes and exercise — Amer. J. Med.70, 201, 1981.
Sestoft L., Trap-Jensen J., Lyngste J., Clansen J. P., Holst J. J., Nielsen S. L., Rehfeld J. E., Sehaffalitzky de Muckadel O.: Regulation of gluconeogenesis and ketogenesis during rest and exercise in diabetic subjects and normal man — Clin. Sci. molec. Med.53, 411, 1977.
Vranic M., Horvath S., Wahren J.: Exercise and diabetes: an overview. Summary of the Conference on Diabetes and Exercise sponsored by the Krac Foundation and held in Santa Ynez, California, March 13–17, 1978 — Diabetes28 (Suppl. 1), 107, 1979.
Wahren J., Hagenfeldt L., Felig P.: Splanchnic and leg exchange of glucose, amino acids and free fatry acids during exercise in diabetes mellitus — J. clin. Invest.55, 1303, 1975.
Williamson D. H.: L-alanine determination with alanine dehydrogenase. In:Bergmeyer H. (Ed.): Methods of enzymatic analysis. 2nd edition. Academic Press, New York, 1974; p. 1679.
This study was supported by theMinistero della Pubblica Instruzione (60%).
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Donatelli, M., Verga, S., Russo, V. et al. The effects of muscular exercise on glucose, free fatty acids, alanine and lactate in type I diabetic subjects in relation to metabolic control. Acta diabet. lat 25, 155–160 (1988). https://doi.org/10.1007/BF02581380
- Muscular exercise
- Type I diabetes mellitus