Summary
Insulin-binding antibodies were sought by a new method in the sera of diabetic patients. They were found in 46% of insulin-treated diabetics and in 15% of the diabetic patients who had never received insulin. None was found in non diabetic control subjects. These results suggest that insulin auto-antibody production may occur in diabetics and that such antibodies may play a role in the pathogenesis or later evolution of the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berson S. A., Yalow R. S.: Some Current Controversies in Diabetes Research - Diabetes14, 549, 1965.
Camerini-Dávalos R.: A Prospective Diagnosis of Diabetes: Prediabetes- In:Penchev I., Popov A., Andreev D., Sirakov L. (Eds): Proc. Intern. Symp. Diabetes, Sofija 1970. BAS, Sofija, 1972; p. 19.
Deckert T.: Autoimmunological Aspects of Diabetes Mellitus - Acta med. scand.476, (Suppl.), 29, 1967.
Gepts W.: Veränderungen in den Langerhans’ schen Inseln beim menschlichen Diabetes - In:Beringer A. (Ed.): Diabetes mellituds. Verl. Wiener med. Akad., Wien, 1970; p. 17.
Ghidoni A., Sorgato G., Sanesi E., Pozza G.: Studio degli anticorpi anti-insulina del siero umano in soggetti normali e diabetici - Acta diabet. lat.5, 173, 1968.
Greenwood F. C., Hunter W. M., Glover J. S.: The Preparation of131I-Labelled Human Growth Hormone of High Specific Radioactivity - Biochem. J.89, 114, 1963.
Grodsky G. M.: Production of Autoantibodies to Insulin in Man and Rabbits - Diabetes14, 396, 1965.
Gurvich A. E., Kuzovleva O. B., Tumanova A. E.: The Use of Antigens on an Insoluble Support - In:Ackroyd J. F. (Ed.): Immunological Methods. Blackwell Sci. Publ., Oxford, 1964; p. 113.
Lunetta M., Calcagno G., Lombardo T., Motta L.: Considerazioni sulla proprietà insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina - Acta diabet. lat.5, 201, 1968.
Páv J., Ježková Z., Škrha F.: Insulin Antibodies - Lancet2, 221, 1963.
Penchev I., Andreev D., Ditzov S.: Insulin-Precipitating Antibodies in Insulin-Treated and Untreated Diabetic Patients - Diabetologia4, 164, 1968.
Reisfeld R. A., Lewis U. J., Williams D. E.: Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide Gels - Nature (Lond.)195, 281, 1962.
Renoid A. E., Young D. A. B.: Reactions immunologiques à l’injection d’insuline homologue et hétérologue -Journées Annuelles de Diabétologie de l’Hôtel-Dieu, Paris 1964. Flammarion Éd., Paris, 1965; p. 25.
Sirakov L. M., Ditzov S. P.: Quantitative Determination of Insulin-Binding Antibodies in Human Serum - Clin. chim. Acta45, 145, 1973.
Author information
Authors and Affiliations
Additional information
Presented at the 7th Annual Meeting of the European Association for the Study of Diabetes, Southampton, 1971.
Deceased April 6, 1974.
Rights and permissions
About this article
Cite this article
Ditzov, S.P., Penchev, I.G., Andreev, D.C. et al. Insulin-binding antibodies in diabetic patients and their relationship to insulin treatment. Acta diabet. lat 11, 106–111 (1974). https://doi.org/10.1007/BF02581310
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02581310