Summary
Fructosamine, a compound used to measure serum glycosylated proteins was assayed in 105 Saudi diabetic subjects and 54 healthy non-diabetic Saudi subjects. Fructosamine concentrations in diabetics were significantly higher than in healthy controls (p<0.0005). Fructosamine concentrations correlated significantly with fasting blood glucose and HbA1 in diabetics (r=0.677, p<0.0005, and r=0.598, p<0.0005, respectively). The correlation between fructosamine and HbA1 was significant in the oral hypoglycemic-treated diabetics and poor in the insulin-treated diabetic group (r=0.568, p<0.0005, and r=0.526, p=0.01). Fructosamine concentrations correlated poorly with the duration of diabetes (r=0.221, p<0.05).
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Ajabnoor M. A., Laajam M. A.: Levels of glucose and glycosylated hemoglobin in Saudi diabetes patients — Trop. geogr. Med.39, 276–280, 1987.
Bacchus R. A., Bell J. L., Madkour M., Kilshaw B.: The prevalence of diabetes mellitus in male Saudi Arabs — Diabetologia23, 330–332, 1982.
Baker J. R., Johnson R. N., Scott D. J.: Serum fructosamine in patients with type II (non-insulin-dependent) diabetes mellitus during changes in management — Brit. med. J.288, 1484–1486, 1984.
Baker J. R., O’Connor J. P., Metcalf P. A., Lawson M. R., Johnson R. N.: Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus — Brit. med. J.287, 863–867, 1983.
Boden G., Master R. W., Gordon S. S., Shuman C. R., Owen O. E.: Monitoring metabolic control in diabetic outpatients with glycosylated hemoglobin — Ann. intern. Med.92, 357–360, 1980.
Dolhofer R., Wieland O. H.: Increased glycosylation of serum albumin in diabetes mellitus — Diabetes29, 417–422, 1980.
Fattany H. H., Mira S. A., El-Zubeir A. G.: The prevalence of diabetes mellitus in rural Saudi Arabia — Diabet. Res. clin. Pract. (Suppl. 1), 1985; abstract # 402.
Goldstein D. E., Parker K. M., England J. D., England J. E. Jr., Wiedmeyer H. M., Rawlings S. S., Hess R., Little R. R., Simonds J. F., Breyfogle R. P.: Clinical application of glycosylated hemoglobin measurements — Diabetes31 (Suppl. 3), 70, 1982.
Graf R. J., Halter J. B., Porte D. Jr.: Glycosylated hemoglobin in normal subjects and subjects with maturity-onset diabetes. Evidence for a saturable system in man — Diabetes27, 834–839, 1978.
Hemoglobin A1 and diabetes: a reappraisal — Brit. med. J.281, 1304–1305, 1980.
Johnson R. N., Metcalf P. A., Baker J. R.: Fructosamine: A new approach to the estimation of serum glycoprotein. An index of diabetic control — Clin. chim. Acta (Amst.)127, 87–95, 1982.
Kennedy A. L., Merimee J.: Glycosylated serum protein and hemoglobin A1 levels to measure control of glycemia — Ann. intern. Med.95, 56–58, 1981.
Kingston M. E., Scales W. R., Woodhouse N. J. Y.: Resistance to ketoacidosis despite severe hyperglycemia in thin adult diabetics — King Faisal Spec. Hosp. med. J.2, 139, 1982.
Lloyd D., Marples J.: Simple colorimetry of glycated serum protein in a centrifugal analyzer — Clin. Chem.30, 1686, 1984.
Lowry H. O., Rosebrough N. J., Farr A. L., Randall R. J.: Protein measurement with the Folin phenol reagent — J. biol. Chem.193, 265–275, 1951.
Mayer T. K., Freedman Z. R.: Protein glycosylation in diabetes mellitus: a review of laboratory measurements and of their clinical utility — Clin. chim. Acta (Amst.)127, 147–184, 1983.
Mosca A., Carenini A., Zoppi F., Carpinelli A., Banfi G., Ceriotti F., Bonini P., Pozza G.: Plasma protein glycation as measured by fructosamine assay — Clin. Chem.33, 1441–1446, 1987.
Skyler J. S.: Complications of diabetes mellitus: relationship to metabolic dysfunction — Diabet. Care2, 499–509, 1979.
Snedecor G. W., Cocharan W. G.: Statistical methods. The Iowa State University Press, Ames/IA, 1973.
Varley H., Gowenlock A. H., Bell M.: Blood glucose and its determination: Trinder’s glucose oxidase method using phenol and 4-aminophenazone in practical clinical biochemistry. 5th Ed. William Heinemann Medical Books Ltd., London, 1980; p. 389.
Wettre S., Arnqvist H. J., Cederblad G., Hermapsson G.: Increase in stable glycosylated hemoglobin after induction of poor glycaemic control — Diabetologia24, 148–151, 1983.
WHO Expert Committee on Diabetes mellitus: Second Report. WHO Tech. Rep. Ser. 464. World Health Organization, Geneva, 1980.
Wilks S. S.: Mathematical statistics. John Wiley, Chichester, 1962.
Yue D. K., Morris K., McLennan S., Turtle J. R.: Glycosylation of plasma protein and its relation to glycosylated hemoglobin in diabetes — Diabetes29, 296–300, 1980.
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Ajabnoor, M.A.M., Zawawi, T.H., Marzouki, K.M.H. et al. Level of serum fructosamine in Saudi diabetic patients. Acta diabet. lat 27, 105–112 (1990). https://doi.org/10.1007/BF02581282
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DOI: https://doi.org/10.1007/BF02581282