Summary
Both early onset and late onset type II diabetes were present in one family of nine siblings. The three early onset type II diabetic siblings showed severe microvascular complications: proliferative retinopathy, diabetic nephropathy, and peripheral neuropathy. Early onset type II diabetes was not associated with any particular HLA haplotype. Early onset type II diabetes could be considered a clinical and genetic disease entity different from MODY type diabetes.
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Scalvini, T., Spandrio, S., di Stefano, O. et al. Severe microvascular disease in type II diabetes of early onset. A family study. Acta diabet. lat 26, 69–74 (1989). https://doi.org/10.1007/BF02581198
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DOI: https://doi.org/10.1007/BF02581198