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Glycated serum proteins and glucose tolerance

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Summary

Glycated serum proteins (GSP), stable glycated hemoglobin (HbA1c) together with some metabolic parameters were evaluated in 120 subjects, 30 with normal glucose tolerance (NGT), 30 with impaired glucose tolerance (IGT), 30 with non-insulin-dependent diabetes mellitus (NIDD), and 30 with insulin-dependent diabetes mellitus (IDD). GSP levels were significantly higher in IGT, NIDD and IDD than in NGT. HbA1c levels were not significantly higher in IGT in comparison with NGT, but were significantly higher in NIDD and in IDD than in NGT and IGT. GSP correlated better than HbA1c with all metabolic parameters considered. Taking into account the distribution of the values, GSP showed a smaller overlap than HbA1c in all four groups studied. Moreover, only 9 subjects (30%) with IGT showed GSP levels above the normal range. Therefore, GSP assay is able to distinguish between normal and diabetic subjects but is unable by itself to discriminate subjects with normal from those with reduced glucose tolerance.

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Authors and Affiliations

  1. Istituto di Medicina Interna, Cattedra di Patologia Medica I dell’Università, Padova

    Annunziata Lapolla, Tiziana Poli, Alessandro Franchin & Anna Barison

  2. Dipartimento di Biostatistica ed Epidemiologia, Laboratorio di Ricerca Fidia, Abano Terme

    Francesca Meneghini & Mauro Zucchetto

  3. Cattedra di Endocrinologia, Università di Palermo, Palermo, Italy

    Domenico Fedele

Authors
  1. Annunziata Lapolla
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  2. Tiziana Poli
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  3. Francesca Meneghini
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  4. Mauro Zucchetto
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  5. Alessandro Franchin
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  6. Anna Barison
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  7. Domenico Fedele
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Additional information

This study was supported by a grant fromConsiglio Nazionale delle Ricerche (Rome, Italy)Progetto Finalizzato ‘Medicina Preventiva e Riabilitativa’, Sottoprogetto ‘Malattie Degenerative’, Ob. 46.

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Lapolla, A., Poli, T., Meneghini, F. et al. Glycated serum proteins and glucose tolerance. Acta diabet. lat 25, 325–332 (1988). https://doi.org/10.1007/BF02581131

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  • DOI: https://doi.org/10.1007/BF02581131

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