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Evaluation of gastrin secretion in diabetic subjects with normal or abnormal cardiovascular autonomic function tests

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Summary

The serum gastrin response to a meat extract drink was measured in 16 non-diabetic subjects, in 40 diabetic subjects and 9 patients with positive tests for gastric parietal cell antibodies. Standard cardiovascular autonomic function tests were also performed in diabetic subjects. The test drink produced a highly significant rise in the serum gastrin concentration (p<0.001). Diabetic subjects with normal cardiovascular autonomic function tests had slightly lower stimulated gastrin concentrations than non-diabetic subjects. In diabetic subjects with abnormal cardiovascular autonomic function tests the distribution of gastrin concentrations after the test drink was bimodal. Eleven out of 20 had 45-min gastrin concentrations >120 pg/ml, compared with 2 out of 20 diabetics with normal cardiovascular autonomic function tests and 1 out of 16 non-diabetic subjects (p<0.001). Much higher gastrin responses were found in 5 out of 9 patients with positive tests for gastric parietal cell antibodies. An increased gastrin response may be found in patients with abnormal autonomic function but its value as a marker is limited by the small amplitude of the change and by the significant prevalence of atrophic gastritis, in which much higher gastrin responses may be found.

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Authors and Affiliations

  1. Department of Endocrinology and Diabetes Mellitus, North Staffordshire Royal Infirmary, Stoke-on-Trent, U. K.

    Martin C. Gulliford, E. John Bicknell & John H. B. Scarpello

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  1. Martin C. Gulliford
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  2. E. John Bicknell
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  3. John H. B. Scarpello
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Gulliford, M.C., Bicknell, E.J. & Scarpello, J.H.B. Evaluation of gastrin secretion in diabetic subjects with normal or abnormal cardiovascular autonomic function tests. Acta diabet. lat 25, 275–282 (1988). https://doi.org/10.1007/BF02581125

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  • DOI: https://doi.org/10.1007/BF02581125

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