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Decrease in whole blood viscosity in alloxan diabetic rabbits

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Summary

Whole blood and plasma viscosity of normal and alloxan diabetic rabbits were measured by means of cone in cone viscosimeters at different shear rates. Blood behaves like a non-Newtonian fluid,i.e. the viscosity is shear rate-dependent whereas plasma viscosity remains constant over the shear rate range employed,i.e. it behaves like a Newtonian fluid. Blood viscosity was found to be statistically significantly decreased in the alloxan diabetic group in comparison to the control group. The decrease is attributed to a slight decrease in mean hematocrit and mean plasma viscosity of the diabetic animals. The possible mechanisms of these changes are discussed.

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References

  1. Gordon W.: The Effect of Ingested Glucose, and Intravenous Injections of Glucose, on the Viscosity of Whole Blood in Man — Clin. Sci.36, 25, 1969.

    PubMed  CAS  Google Scholar 

  2. Grigoleit H.-G., Ganser V.: Erhöhung der Blutviskosität bei Kaninchen durch Äthinylöstradiol — Med. Welt (Stuttg.)24, 2085, 1973.

    PubMed  CAS  Google Scholar 

  3. Grigoleit H.-G., Lehrach F.: Blutviskosität und Diabetes mellitus — Med. Mschr.27, 353, 1973.

    PubMed  CAS  Google Scholar 

  4. Grigoleit H.-G., Lehrach F., Müller R.: Diabetic Angiopathy and Blood Viscosity — Acta diabet. lat.10, 1311, 1973.

    Google Scholar 

  5. Lassman H. B., Wilkens H. J., Back N.: Biochemical Pharmacology of the Fibrinolysin System of the Rat. I. The Effect of Alloxan-Induced Hyperglycemia — J. Pharmacol. exp. Ther.189, 317, 1974.

    PubMed  CAS  Google Scholar 

  6. Meiselman H. J., Cokelet G. R.: Blood Rheology — Advanc. Microcirc.5, 32, 1973.

    Google Scholar 

  7. Meiselman H. J., Merrill E. W., Gilliland E. R., Pelletier G. A., Salzman E. W.: Influence of Plasma Osmolarity on the Rheology of Human Blood — J. appl. Physiol.22, 772, 1967.

    PubMed  CAS  Google Scholar 

  8. Rasmussen S. N.: Influence of Plasma Hypertonicity on Blood Viscosity Studied in Vitro and in an Isolated Vascular Bed — Acta physiol. scand.84, 472, 1972.

    Article  PubMed  CAS  Google Scholar 

  9. Schermer S.: Die Blutmorphologie der Laboratoriumstiere — J. A. Barth, Leipzig, 1958; p. 23.

    Google Scholar 

  10. Siegenthaler W.: Klinische Pathophysiologie — Georg Thieme Verlag, Stuttgart, 1970; p. 183.

    Google Scholar 

  11. Skovborg F.: Blood Viscosity in Normal and Diabetic Subjects — Thesis, Fadl’s Forlag, København, 1974.

    Google Scholar 

  12. Spinelli F. R., Meier Ch. D.: Measurement of Blood Viscosity (1) — Biorheology11, 306, 1974.

    Google Scholar 

  13. Weed R. I., Reed C. F.: Membrane Alterations Leading to Red Cell Destruction — Amer. J. Med.41, 681, 1966.

    Article  PubMed  CAS  Google Scholar 

  14. Zingg W., Wilson R. B., Morgan C. D., Anderson D. E.: Rheological Properties of Blood from Diabetic Wistar Rats — Canad. J. Physiol. Pharmacol.49, 927, 1971.

    CAS  Google Scholar 

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With the technical assistance of A. Lahham and G. Jacobi.

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Grigoleit, HG. Decrease in whole blood viscosity in alloxan diabetic rabbits. Acta diabet. lat 12, 72–78 (1975). https://doi.org/10.1007/BF02581114

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