Summary
Biopsy material obtained from the first portion of the jejunum of 56 unselected diabetics and 21 normal controls was examined under the electron microscope (in 8 cases) or with a method of stereologic morphometry. Controls were found to have a villous volume (VVi) of 50.19±10.1%. All values below 40% were interpreted as an expression of deterioration of the mucous membrane. Altogether 12.5% of the diabetics showed total atrophy, and 20% had significant reduction of VVi. These changes did not correlate with intestinal disorders or other signs of diabetes. In total atrophy histochemical changes could be demonstrated. Microangiopathy was not observed in the intestinal mucosa.
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Bargen J. A., Bollman J. L., Kepler E. J.: Diarrhea of Diabetes, and Steatorrhea of Pancreatic Insufficiency — Proc. Mayo Clin.11, 737, 1936.
Berge K. G., Sprague R. G., Bennet W. A.: The Intestinal Tract in Diabetic Diarrhea; a Pathologic Study — Diabetes5, 289, 1956.
Berge K. G., Wollaeger E. E., Scholz D. A., Rooke E. D., Sprague R. G.: Steatorrhea Complicating Diabetes Mellitus with Neuropathy; Report of Cases without Apparent External Pancreatic Insufficiency — Diabetes5, 25, 1956.
Bojsen-Möller F., Gronbaek P., Rostgaard J.: Light Microscopic Study of Gastrointestinal and Skin Capillaries in Diabetes Mellitus — Diabetes12, 429, 1963.
Bridwell T.: Peroral Jejunal Biopsy in a Patient with Diabetic Diarrhea — Diabetes10, 58, 1961.
Buchan D. J.: Jejunal Biopsy in Diabetic Steatorrhea: a Case Report — Gastroenterology42, 193, 1962.
Cantor D. S., Nasca S., Perez V., Chiocca I.: Diabetic Steatorrhea — Acta Gastroenterológica Latino-Americana1, 163, 1969.
Corsini G., Gandolfi E., Bonechi I., Cerri B.: Fat Absorption in Diabetes Mellitus — Diabetes16, 455, 1967.
de Guillerman S. W., de Pini A. S. F., de Buera A. C., Raizman H.: Esteatorrea y diabetes en pediatría — Arch. argent. Pediat.71, 110, 1973.
Ellenberg M.: Diabetic Neuropathy with Special Reference to Visceral Neuropathy — Advanc. intern. Med.12, 11, 1964.
Ellenberg M., Bookman J.: Diabetic Diarrhea with Malabsorption Syndrome — Diabetes9, 14, 1960.
Faerman I., Glocer L., Celener D., Jadzinsky M., Fox D., Maler M., Alvarez E.: Autonomic Nervous System and Diabetes. Histological and Histochemical Study of the Autonomic Nerve Fibers of the Urinary Bladder in Diabetic Patients — Diabetes22, 225, 1973.
Goldstein F., Wirts C. W., Kowlessar O. D.: Diabetic Diarrhea and Steatorrhea. Microbiologic and Clinical Observations — Ann. intern. Med.72, 215, 1970.
Goyal R. K., Spiro H. M.: Gastrointestinal Manifestations of Diabetes Mellitus — Med. Clin. N. Amer.55, 1031, 1971.
Green P. A., Berge K. G., Sprague R. G.: Control of Diabetic Diarrhea with Antibiotic Therapy — Diabetes17, 385, 1968.
Green P. A., Wollaeger E. E., Sprague R. G., Brown A. L.: Diabetes Mellitus Associated with Non-Tropical Sprue. Report of 4 Cases — Diabetes11, 388, 1962.
Hindle W., Craemer B.: Significance of Small Intestinal Biopsy — Brit. med. J.2, 455, 1965.
Hodges F. J., Rundles R. W., Hanelin J.: Roentgenologic Study of the Small Intestine. II. Dysfunction Associated with Neurologic Diseases — Radiology49, 659, 1947.
Hoost C., Devos E., Kriekermas J., van Damme J.: Malabsorption and Diabetes Mellitus in Children — Helv. pediat. Acta23, 478, 1968.
Jadzinsky M., Faerman I., Fox D.: Neuropatía diabética visceral — Acta diabet. lat.10, 208, 1973.
Joslin E. P., Root H. F., White P., Marble A. (Eds): The Treatment of Diabetes Mellitus — Lea & Febiger, Philadelphia, 1952.
Katz L. A., Spiro H. M.: Gastrointestinal Manifestation of Diabetes — New Engl. J. Med.275, 1350, 1966.
Komrover G.: Celiac Disease in a Diabetic Child — Lancet1, 1215, 1969.
Laguens R.: Morphometric Study of Myocardial Mitochondria in the Rat — J. Cell Biol.48, 673, 1971.
Luft J. M.: Improvements in Epoxy Resin Embedding Methods — J. biophys. biochem. Cytol.9, 409, 1961.
Malins J. M., French J.: Diabetic Diarrhea — Quart. J. Med.26, 467, 1957.
Malins J. M., Mayne N.: Diabetic Diarrhea: a Study of 13 Patients with Jejunal Biopsy — Diabetes18, 858, 1969.
Rosan R., Schwachman H., Kulczycki L.: Diabetes Mellitus and Cystic Fibrosis of the Pancreas — Amer. J. Dis. Child.104, 625, 1962.
Rundles R. W.: Diabetic Neuropathy. General Review with Report of 125 Cases — Medicine (Baltimore)24, 111, 1945.
Sheridan E. P., Bailey C. C.: Diabetic Nocturnal Diarrhea — J. Amer. med. Ass.130, 632, 1946.
Sires J., Cassano I., Games R., Patane S., de Larrechea I.: Diabetes mellitus y enfermedad celíaca en el niño — Rev. Soc. argent. Diabetes4 (Suppl. 1), 121, 1970.
Sprague R. G.: Steatorrhea in Diabetic Patients — Diabetes11, 436, 1962.
Sumi S. M., Finlay J.: On the Pathogenesis of the Diabetic Diarrhea — Ann. intern. Med.55, 994, 1961.
Vinnik I. E., Kern F., Sussman K. E.: Malabsorption and Diarrhea of Diabetes Mellitus — Gastroenterology13, 507, 1962.
Walker Smith J., Grigor W.: Celiac Disease in a Diabetic Child — Lancet1, 1021, 1969.
Weibel E. R.: Morphometry of the Human Lung — Academic Press, New York, 1963.
Weibel E. R., Staubli S., Ghagi H. R., Hess F. A.: Correlated Morphometric and Biochemical Studies of the Liver Cell. Morphometric Model, Stereological Methods, and Normal Morphometric Data for Rat Liver — J. Cell Biol.42, 68, 1969.
Whalen G. E., Soergel K. H., Geenen J. E.: Diabetic Diarrhea. A Clinical and Pathophysiological Study — Gastroenterology56, 1021, 1969.
Wruble L. D., Kalser M. H.: Diabetic Steatorrhea: Distinct Entity — Amer. J. Med.37, 118, 1964.
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Cabarrou, A., Schaposnik, F., Costa Gil, J.E. et al. The small intestine in diabetes mellitus. Correlation of clinical phenomena to histomorphometric findings in peroral biopsy material. Acta diabet. lat 12, 9–23 (1975). https://doi.org/10.1007/BF02581108
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DOI: https://doi.org/10.1007/BF02581108