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Lack of influence of arginine preloading on the insulin response to I.V. glucagon in children and adolescents

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Summary

Nine normal children (6 males and 3 females) aged from 7 1/2 to 14 1/2 years underwent a 30-min arginine infusion (0.5 g/kg) followed at 90 min by one bolus i.v. glucagon injection (0.03 mg/kg). On a separate occasion the same children underwent an i.v. glucagononly test. No significant difference was found when the glucose and insulin responses in the two glucagon tests were compared, in contrast to previous findings that preloading with glucose resulted in a significantly increased response of insulin to glucagon.

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Authors and Affiliations

  1. Sackler School of Medicine, Tel Aviv University, Tel Aviv

    Ilana Blum, Michael Doron & Zvi Laron

  2. Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center, Petah Tikva, Israel

    Ilana Blum, Michael Doron & Zvi Laron

Authors
  1. Ilana Blum
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  2. Michael Doron
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  3. Zvi Laron
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Established Investigator of the Chief Scientist’s Bureau Ministry of Health.

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Blum, I., Doron, M. & Laron, Z. Lack of influence of arginine preloading on the insulin response to I.V. glucagon in children and adolescents. Acta diabet. lat 15, 68–71 (1978). https://doi.org/10.1007/BF02581008

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  • DOI: https://doi.org/10.1007/BF02581008

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