Summary
A retrospective study of 215 deliveries in diabetic mothers atHospital de Clínicas (Montevideo, Uruguay) has been performed. Presence of congenital malformations (CM) was considered in relation to age of the mothers, class of maternal diabetes, maternal angiopathy, treatment and metabolic control. The prevalence of CM in the series was 9.8%. None of the factors analyzed seems to be statistically linked to the prevalence of CM.
Similar content being viewed by others
References
Caldera R.: Carbutamide et malformations chez l’enfant — Ann. Pédiat.17, 432, 1970.
Chosson J.: Quoted by:Rivière M. (Ed.): États prédiabétiques et grossesse. Masson et Cie Éd., Paris, 1965; p. 27.
Chung C. S., Myrianthopoulos N. C.: Racial and Prenatal Factors in Major Congenital Malformations — Amer. J. hum. Genet.20, 44, 1968.
Comess L. J., Bennett P. H., Burch T. A., Miller M.: Congenital Anomalies and Diabetes in the Pima Indians of Arizona — Diabetes18, 471, 1969.
Constam G. R., Rust Th., Willi H.: Diabetes and Pregnancy — Acta diabet. lat.8, 26, 1971.
Dittmar F. W., Mehnert H.: Diabetes Mellitus and Pregnancy — Acta diabet. lat.9, 2, 1972.
Douglas C. P., Richard R.: Use of Chlorpropamide in the Treatment of Diabetes in Pregnancy — Diabetes16, 60, 1967.
Driscoll S. G., Benrschke K., Curtis G. W.: Neonatal Deaths among Infants of Diabetic Mothers — Amer. J. Dis. Child.100, 818, 1960.
Drury M. I.: Pregnancy in the Diabetic — Diabetes15, 830, 1966.
Dunn P. M.: Congenital Malformations and Maternal Diabetes — Lancet1, 644, 1964.
Farquhar J. W.: The Child of the Diabetic Woman — Arch. Dis. Childh.34, 76, 1959.
Hagbard L.: Pregnancy and Diabetes Mellitus — Ch. C Thomas, Springfield/Ill., 1961; p. 21.
Hoet J. J., Gommers A., Hoet J. P.: Clinical Data on Selected Cases of Prediabetes — In:Oberdisse K., Jahnke K. (Eds): Diabetes Mellitus. III. Kongr. Int. Diabetes Fed., Düsseldorf 1958. Georg Thieme, Stuttgart, 1959; p. 529.
Hoet J. P.: Prédiabète — In:Oberdisse K., Jahnke K. (Eds): Diabetes Mellitus. III. Kongr. Int. Diabetes Fed., Düsseldorf 1958. Georg Thieme Verlag, Stuttgart, 1959; p. 524.
Hultquist G. T.: Morphology of Endocrine Organs in Infants of Diabetic Mothers — In:Rodriguez R. R., Vallance-Owen J. (Eds): Diabetes. 7th Congr. Int. Diabetes Fed., Buenos Aires 1970. Excerpta Medica Foundation, Amsterdam, 1971; p. 686.
Jackson W. P. U., Campbell G. D., Notelowitz M., Blumensohn D.: Tolbutamide and Chlorpropamide during Pregnancy in Human Diabetics — Diabetes11 (Suppl.), 98, 1962.
Kalitzki M.: Congenital Malformations and Diabetes — Lancet1, 641, 1965.
Karlsson K., Kjellmer I.: The Outcome of Diabetic Pregnancies in Relation to the Mother’s Blood Sugar Level — Amer. J. Obstet. Gynec.112, 213, 1972.
Kuding N., Root H., Marble A.: Importance of Control of Diabetes in Prevention of Vascular Complications — J. Amer. med. Ass.150, 904, 1952.
Kyle G. C.: Diabetes and Pregnancy — Ann. intern. Med.59 (Suppl. 3), 1, 1963.
López-Quijada C., Chiva Carrion L.: Maternal Disorders of Carbohydrate Metabolism in Cases of Cardiac Embryopathy — Act diabet. lat.11, 140, 1974.
Mitchell S. C., Sellmann A. H., Westphal M. C., Park J.: Etiologic Correlates in a Study of Congenital Heart Disease in 56,109 Births — Amer. J. Cardiol.28, 653, 1971.
Navarrete V. N., Torres I. H., Rivera I. R., Shor V. P., Gracia P. M.: Maternal Carbohydrate Disorder and Congenital Malformations — Diabetes16, 127, 1967.
Nora J.: Factores etiológicos de las cardiopatías congénitas — Pediat. Clin. N. Amer.11, 1059, 1971.
Paley R. G., Higgins F. E.: Children of Diabetic Mothers — In:Oberdisse K., Jahnke K. (Eds): Diabetes Mellitus. III. Kongr. Int. Diabetes Fed., Düsseldorf 1958. Georg Thieme Verlag, Stuttgart, 1959; p. 575.
Pedersen J.: The Pregnant Diabetic and her Newborn — Munksgaard, Copenhagen, 1967.
Pedersen L. M., Tygstrup I., Pedersen J.: Congenital Malformations in Newborn Infants of Diabetic Women; Correlation with Maternal Diabetic Vascular Complications — Lancet1, 1124, 1964.
Rowland Th., Hubbell J., Nadas A.: Congenital Heart Disease in Infants of Diabetic Mothers — J. Pediat.83, 815, 1973.
Senanez H., Kolski R., Mane Garzon F.: Malformaciones congénitas en 6876 recién nacidos — Arch. Pediat. Urug.46, 18, 1975.
Temesio P.: Prediabetes y diabetes latente — Rev. méd. Urug.7, 97, 1970.
Warren S., LeCompte Ph., Leeg M.: The Pathology of Diabetes Mellitus — Lea & Febiger, Philadelphia, 1966; p. 427.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Temesio, P., Belitzky, R., Gallego, L. et al. Congenital malformations in diabetic offspring. Acta diabet. lat 14, 192–198 (1977). https://doi.org/10.1007/BF02580967
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02580967