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Human keratinocytes express functional α-MSH (MC1-R) receptors

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References

  • Ao, Y.; Park, H. Y.; Olaizola-Horn, S.; Gilchrest, B. A. Activation of cAMP dependent protein kinase is required for optimal α-melanocyte stimulating hormone induced pigmentation. Exp. Cell Res. 244:117–124; 1998.

    Article  PubMed  CAS  Google Scholar 

  • Chakroborty, A. K.; Funasaka, Y.; Pawelek, J. M.; Nagahama, M.; Ito, A.; Ichihashi, M. Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis. J. Investig. Dermatol. 112:853–860; 1999.

    Article  Google Scholar 

  • Eberle, A. N., editor. The melanotropins. In: Chemistry, physiology and mechanism of action. New York: S. Karger, 1988.

  • Ichiyama, T.; Sakai, T.; Catania, A.; Barsh, G.; Furukawa, S.; Lipton, J. Systemically administered α-melanocyte stimulating peptides inhibit NF-kB activation in experimental brain inflammation. Brain Res. 836:31–37; 1999.

    Article  PubMed  CAS  Google Scholar 

  • Jiang, J.; Sharma, S. D.; Hruby, V. J.; Fink, J. L.; Hadley, M. E. Human epidermal melanocyte and keratinocyte melanotropin receptors: visualization by melanotropic peptide conjugated macrospheres (polyamide beads). Exp. Dermatol. 6:6–12; 1997.

    Article  PubMed  CAS  Google Scholar 

  • Luger, T.; Paus, R.; Slominski, A.; Lipton, J. Cutaneous neuromodulation: the proopiomelanocortin system. Ann. NY Acad. Sci. 885:1–479; 1999.

    Google Scholar 

  • Luger, T. A.; Scholzen, T.; Brzoska T.; Becher, E.; Slominski A.; Paus, R. Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann. NY Acad. Sci. 840:381–394; 1998.

    Article  PubMed  CAS  Google Scholar 

  • Mitra, R.; Nickoloff, B. Cultivation of human epidermal keratinocytes in serum-free growth medium. In: Leigh, I.; Watt, F., ed. Keratinocyte methods. New York: Cambridge University Press; 1994; 17–19.

    Google Scholar 

  • Mountjoy, K. G.; Robbins, L. S.; Mortrud, M. T.; Cone, R. D. The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248–1251; 1992.

    Article  PubMed  CAS  Google Scholar 

  • Orel, L.; Simon, M. M.; Karlseder, J.; Bhardwaj, R., et al. α-melanocyte stimulating hormone downregulates differentiation driven heat shock protein 70 expression in keratinocytes. J. Investig. Dermatol. 4:401–405; 1997.

    Article  Google Scholar 

  • Slominski, A.; Heasley, D.; Ermak, G.; Mazurkiewicz, J. E.; Baker, J.; Carlson, A. Expression of proopiomelanocortin (POMC) derived melanocyte stimulating hormone (MSH) and ACTH peptides in skin of basal cell carcinoma patients. Hum. Pathol. 130:208–215; 1999.

    Article  Google Scholar 

  • Slominski, A.; Mihm, M. Potential mechanism of skin response to stress. J. Dermatol. 35:849–851; 1996.

    Article  CAS  Google Scholar 

  • Slominski, A.; Paus, R.; Wortsman, J. On the potential role of proopiomelanocortin in skin physiology and pathology. Mol. Cell. Endocrinol. 93:C1-C6; 1993.

    Article  PubMed  CAS  Google Scholar 

  • Slominski, A.; Pawelek, J. Animals under the sun: effects of ultraviolet radiation on mammalian skin. Clin. Dermatol. 16:503–515; 1998.

    Article  PubMed  CAS  Google Scholar 

  • Slominski, A.; Wortsman, J.; Luger, T.; Paus, R.; Solomon, S. Corticotropin releasing hormone and proopiomelanocortin involvement in a stress response of the skin. Physiol. Rev. 80:979–1020; 2000.

    PubMed  CAS  Google Scholar 

  • Suzuki, I.; Cone, R. D.; Im, S.; Nordlund, J.; Abdel-Malek, Z. Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137:1627–1633; 1996.

    Article  PubMed  CAS  Google Scholar 

  • Taherzadeh, S.; Sharma, S.; Chhajlani, V., et al. α-MSH and its receptors in regulation of tumor necrosis factor-α production by human monocyte/macrophages. Am. J. Physiol. 276:R1289-R1294; 1999.

    PubMed  CAS  Google Scholar 

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Correspondence to Jonathan L. Curry.

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Curry, J.L., Pinto, W., Nickoloff, B.J. et al. Human keratinocytes express functional α-MSH (MC1-R) receptors. In Vitro Cell.Dev.Biol.-Animal 37, 234–236 (2001). https://doi.org/10.1007/BF02577535

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