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Technique and results of “higher-dose” infusion

  • II. Techniques of Fibrinolysis in Peripheral Arterial Occlusions
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Abstract

We experimented with thrombolytic technique in an attempt to maximize therapeutic outcome, selecting urokinase because of its proven safety and efficacy in clinical investigation. An initially “high-dose” regimen, starting at 4,000 U/min and decreasing to 1,000 U/min after restoration of antegrade blood flow, generally establishes lysis within 3–4 h—even after acute embolic or thrombolytic occlusion. It can also be used effectively and safely as a therapeutic trial. “High-dose” urokinase compares favorably with “low-dose” streptokinase and shows a lower incidence of bleeding and allergic complications.

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Authors and Affiliations

  1. Washoe Medical Center, University of Nevada-Reno, 77 Pringle Way, 89520, Reno, Nevada, USA

    Thomas McNamara M.D.

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  1. Thomas McNamara M.D.
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McNamara, T. Technique and results of “higher-dose” infusion. Cardiovasc Intervent Radiol 11 (Suppl 1), S48–S57 (1988). https://doi.org/10.1007/BF02577097

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  • DOI: https://doi.org/10.1007/BF02577097

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