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Effect of ursodeoxycholic acid on biochemical parameters, hepatocyte proliferation and liver histology in galactosamine hepatitis in the rat

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Research in Experimental Medicine

Abstract

The effect of oral administration of ursodeoxycholic acid (UDCA) on biochemical parameters, liver histology and liver cell proliferation was investigated in rats with galactosamine hepatitis. Treatment with UDCA led to a decrease of aminotransferases, but did not show any significant changes in liver histology or liver cell proliferation. The improvement of liver enzymes without change of histology in this animal model of hepatitis following treatment with UDCA is in agreement with results obtained from clinical trials with UDCA in patients with chronic viral hepatitis.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, University of Heidelberg, Heidelberg, Germany

    Jochen Rudi, Thorsten Schlenker & Wolfgang Stremmel

  2. Department of Medicine, St. Josefs-Hospital, Wiesbaden, Germany

    Richard Raedsch

  3. Department of Pathology, University of Heidelberg, Heidelberg, Germany

    Rüdiger Waldherr

  4. Division of Clinical Chemistry, Department of Medicine, University of Heidelberg, Heidelberg, Germany

    Markus Zorn

Authors
  1. Jochen Rudi
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  2. Thorsten Schlenker
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  3. Richard Raedsch
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  4. Rüdiger Waldherr
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  5. Markus Zorn
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  6. Wolfgang Stremmel
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Rudi, J., Schlenker, T., Raedsch, R. et al. Effect of ursodeoxycholic acid on biochemical parameters, hepatocyte proliferation and liver histology in galactosamine hepatitis in the rat. Res. Exp. Med. 195, 309–315 (1995). https://doi.org/10.1007/BF02576801

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  • DOI: https://doi.org/10.1007/BF02576801

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