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Biochemical and biophysical alterations of lipoprotein after liver transplantation from a living related donor

A biochemical and proton NMR study

  • Original Papers
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Research in Experimental Medicine

Abstract

Changes in lipoprotein metabolism after liver transplantation from living related donors were investigated in nine pediatric patients by means of biochemical and proton nuclear magnetic resonance (NMR) analyses of lipoprotein. NMR offers rapid and nondestructive measurement of lipoprotein. The ratio of esterified cholesterol to total cholesterol, expected to be a prognostic indicator after liver transplantation, was low before the operation (0.44) and recovered to over 0.6 at 3 weeks. The half line width of the methylene peak of lipoprotein, as measured by proton NMR, was correlated with the ratio of esterified cholesterol to total cholesterol. It is suggested that proton NMR analysis can provide information about the biophysical changes in lipoprotein associated with liver transplantation.

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Authors and Affiliations

  1. Second Department of Surgery, Faculty of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyoku, 606, Kyoto, Japan

    Shingo Iwata, Akira Tanaka, Kaoru Sano, Shinji Uemoto, Toshiyuki Kitai, Yoshio Yamaoka, Koichi Tanaka & Kazue Ozawa

  2. Molecular Neurobiology Research Center, Shiga University of Medical Science, Tsukinowacho Seta, 520-21, Otsu, Shiga, Japan

    Toshiro Inubushi

Authors
  1. Shingo Iwata
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  2. Akira Tanaka
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  3. Toshiro Inubushi
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  4. Kaoru Sano
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  5. Shinji Uemoto
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  6. Toshiyuki Kitai
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  7. Yoshio Yamaoka
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  8. Koichi Tanaka
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  9. Kazue Ozawa
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Iwata, S., Tanaka, A., Inubushi, T. et al. Biochemical and biophysical alterations of lipoprotein after liver transplantation from a living related donor. Res. Exp. Med. 194, 313–320 (1994). https://doi.org/10.1007/BF02576393

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  • DOI: https://doi.org/10.1007/BF02576393

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