Abstract
Conflicting results have been reported on the effect of famotidine on cardiac performance and visceral hemodynamics, studied by non-invasive techniques. It is for that reason that we used the radioactive microsphere technique to study the effect of famotidine on cardiac performance in the rat. Hepatic blood flow (HBF) and portal blood flow (PBF) were measured during the same experiment. Rats were either given famotidine (2.0 mg/kg per day) or drinking water for 7 days through an orogastric tube. Administration of famotidine had no effect on cardiac output (CO), HBF, PBF, or liver blood flow (LBF), which is the sum of HBF and PBF. In both groups, LBF consisted of a similar fraction of CO, 14.5±3.9% and 15.7±4.38%, in the control and the famotidine groups, respectively. Pulse rate, systolic pressure and left ventricular contractility were not affected by famotidine. It is concluded that in the rat, administration of famotidine for 7 days has no effect on systemic, hepatic or portal hemodynamics.
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Levi R, Owen DAA, Trzeciakowski J (1982) Actions of histamine on the heart and vasculature; In: Ganellin CR, Parsons M (eds) Pharmacology of histamine receptors. Wright, London, pp 236–297
Baumann G, Felix SB, Schrader CD, Heidecke CD, Riess G, Erhardt WD (1981) Cardiac contractile and metabolic effects mediated via the myocardial H2-receptor adenylate cyclase system: characterization of two new specific H2-receptor-agonists, impromidine and dimaprit, in the guinea pig and human myocardium. Res Exp Med 179:81–98
Baumann G, Schrader J, Gerlach E (1981) Inhibitory action of adenosine on histamine- and dopamine-stimulated cardiac contractility and adenylate cyclase in guinea pigs. Circ Res 48:259–266
Baumann G, Loher U, Felix SB, Heidecke CD, Riess G, Ludwig L, Blomer H (1982) Deleterious effects of cimetidine in the presence of histamine on coronary circulation. Possible clinical implications in anaphylactic states in individuals with coronary heart disease. Res Exp Med 180:209–213
Ginsburg R, Bristow MR, Stinson EB, Harrison DC, (1980) Histamine receptors in the human heart. Life Sci 26:2245–2249
Kirch W, Halabi A, Linde M, Santos SR (1989) Negative effects of famotidine on cardiac performance assessed by non-invasive hemodynamic measurements. Gastroenterology 96: 1388–1392
Kirch W, Halabi A, Ohnhaus EE (1987) Negative inotropic effects of famotidine. Lancet II:684–685
Kirch W, Halabi A, Ohnhaus EE (1988) Negative inotropic effects of famotidine. Schweiz Med Wochenschr [Suppl 23] 118:4
Kirch W, Halabi A, Ohnhaus EE (1988) Negative inotropic effects of famotidine. Klin Wochenschr [Suppl 13] 66:200–201
Kirch W, Halabi A, Ohnhaus EE (1988) Negative inotropic effects of famotidine. Clin Pharmacol Ther 43:163
Kirch W, Halabi A, Linde M, Ohnhaus EE (1988) Negative inotropic action of famotidine. Schweiz Med Wochenschr 118:1912–1914
Matsukawa S, Hoshi K, Kaise A, Sasaki I, Hashimoto Y, Amaha K (1986) The cardiovascular effect of famotidine in intensive care patients. Intensive Care Med 10:763–767
Omote K, Namiki A, Sumita S, Takahashi T, Ujike Y, Hagiwara T (1987) Comparative studies on hemodynamic effects of intravenous cimetidine, ranitidine and famotidine in intensive care unit patients. Masui 36:940–947
Salmon P, Darragh A, Fitzgerald D, Lambe R, Hirata Y (1989) Multiple dose hemodynamic study of famotidine in healthy male volunteers. Eur J Clin Pharmacol [Suppl] A136
Feely J, Wickinson GR, Wood AJJ (1981) Reduction of liver blood flow and propranolol metabolism by cimetidine. N Eng J Med 304:692–695
Garg DC, Wedler DJ, Jallad NS, Eshelman FN (1982) The effects of ranitidine and cimetidine on hepatic blood flow. Clin Pharmacol Ther 31:228–229
Bruck R, Krepel Z, Bar-Meir S (1988) Lack of effect of cimetidine on indocyanine green extraction and clearance by the rat liver. Isr J Med Sci 24:349–350
Daneshmend TK, Ene MD, Parker G, Roberts CJC (1984) Effects of chronic oral cimetidine on apparent liver blood flow and hepatic microsomal enzyme activity in man. Gut 25:125–128
Tyden G, Thulin L, Nyberg B (1983) The effect of cimetidine on liver blood flow in anesthetized man. Acta Chir Scand 149:303–305
Donn KH, Powell JR, Rogers JF, Plachetka JR (1984) Lack of effect of histamine H2-recepter antagonists on indocyanine green disposition measured by two methods. J Clin Pharmacol 24:360–370
Ohnishi K, Saito M, Nomura F, Okuda K, Suzuki N, Ohtsuki T, Goto N, Takashi M (1987) Effect of famotidine on hepatic hemodynamics and peptic ulcer. Am J Gastroenterol 82: 415–418
Randolph AM, Heymann MA (1967) The circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21:163–184
Bartum RJ, Berkowitz DM, Hollenberg NK (1974) A simple radioactive microsphere method for measuring regional blood flow. Invest Radiol 9:126–132
Malik AB, Kaplan JE, Saba TM (1976) Reference sample method for cardiac output and regional blood flow determination in the rat. J Appl Physiol 40:472–497
Ishise S, Pegram BL, Yamamoto J, Kitamura Y, Frohlich ED (1980) Reference sample microsphere method: cardiac output and blood flows in conscious rats. Am J Physiol 239:H443-H449
Salomon PS, Fitzgerald D, Kenny M (1991) No effect of famotidine on cardiac performance by non-invasive hemodynamic measurements. Clin Pharmacol Ther 49:589–595
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Melzer, E., Bardan, E., Krepel, Z. et al. Famotidine has no effect on cardiac performance and liver blood flow in the rat. Res. Exp. Med. 194, 179–184 (1994). https://doi.org/10.1007/BF02576378
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DOI: https://doi.org/10.1007/BF02576378