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Age-related alterations in second-messenger systems in the gerbil brain: autoradiographic analysis and effect of vinconate

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Research in Experimental Medicine

Summary

Age-related alterations in binding sites of major second-messenger systems in the gerbil brain were analyzed by receptor autoradiography using [3H]phorbol 12, 13-dibutyrate (PDBu), and [3H]inositol 1,4,5-trisphosphate (IP3). In middle-aged gerbils (16 months old), the reduction of PDBu-binding sites was noticed in various brain regions compared with young animals (4 weeks old). By contrast, the elevation of IP3-binding sites was seen in most of brain regions except for the reduction in the cerebellum in the middle-aged animals. Chronic treatment with vinconate partly regulated the age-related changes in the binding sites of these second messengers. The result demonstrates the age-related alterations in the binding sites of an intracellular second-messenger system. Furthermore, they suggest that vinconate partly modulates the age-related alterations in the bindings of second messengers.

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Authors and Affiliations

  1. Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan

    Tsutomu Araki, Hiroyuki Kato & Kyuya Kogure

  2. Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe, 115, Tokyo, Japan

    Tsutomu Araki, Yasuo Kanai & Yukiharu Ishida

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  1. Tsutomu Araki
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  2. Yasuo Kanai
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  3. Hiroyuki Kato
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  4. Kyuya Kogure
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  5. Yukiharu Ishida
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Araki, T., Kanai, Y., Kato, H. et al. Age-related alterations in second-messenger systems in the gerbil brain: autoradiographic analysis and effect of vinconate. Res. Exp. Med. 192, 221–230 (1992). https://doi.org/10.1007/BF02576278

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  • DOI: https://doi.org/10.1007/BF02576278

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