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Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 MICE

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Research in Experimental Medicine

Summary

The present study examined the influence of systemic administration of neuroactive drugs on delayed-type hypersensitivity (DTH) in C57BL/6 mice. The cholinergic agonist nicotine and the acetylcholineesterase inhibitor physostigmine decreased DTH, whereas the alpha-adrenergic agonist clonidine stimulated DTH. In contrast isoprenaline, a specific β-adrenergic agonist suppressed DTH. It is concluded from these observations that the autonomic nervous system modulates those processes governing DTH. It seems that the alpha-adrenergic subsystem stimulates, whereas the β-adrenergic subsystem and the parasympathicus inhibit DTH.

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Authors and Affiliations

  1. Department of Animal Models, Institute of Microbiology and Experimental Therapy, Beutenbergstrasse 11, O-6900, Jena, Federal Republic of Germany

    B. Günther & P. Clausing

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  1. B. Günther
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  2. P. Clausing
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Günther, B., Clausing, P. Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 MICE. Res. Exp. Med. 192, 123–130 (1992). https://doi.org/10.1007/BF02576266

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  • DOI: https://doi.org/10.1007/BF02576266

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