Summary
In the CBA/J (H-2k)×DBA/2J (H-2d) murine model, the protective value of pooled murine immunoglobulin i.p. was compared with that of serum taken 7 days after termination of CBA/J (H-2k)×BALB/c (H-2d) pregnancy. A control group of CBA/J females received treatment with autologous virgin serum. CBA/J females at 7 weeks of age were injected 3 days before mating with DBA/2J males and 3 days after sighting of the vaginal plug. An effect of treatment can be shown following IgG therapy (P<0.05). The highest rate of viable fetuses was documented in the immunoglobulin-treated females, while the rate of viable offspring did not differ in the two serum-treated animal groups.
Similar content being viewed by others
References
Basta M, Kirshbom P, Frank MM, Fries LF (1989) Mechanism of therapeutic effect of high dose intravenous immunoglobulin. J Clin Invest 84:1974
Brand A, Witvliet M, Claas FHJ (1988) Beneficial effect of intravenous gammaglobulin in a patient with complement—mediated autoimmune thrombocytopenia due to IgM—antiplatlet antibodies. Br J Haematol 69:507–511
Carreras LO, Perez GN, Vega HR, Casavilla F (1988) Lupus anticoagulant and recurrent fetal loss: successful treatment with gammalobulin. Lancet II:393–394
Chaouat G, Kiger N, Wegmann TG (1983) Vaccination against spontaneos, abortion in mice. J Reprod Immunol 5:389–392
Chaouat G, Kolb JP, Kiger N, Stanislawski N, Wegmann T (1985) Immunologic consequences of vaccination against abortion in mice. J Immunol 134:1594–1598
Chaouat G, Kolb JP, Riviere M, Chaffaux S (1985) Local and systemic regulation of maternal antifetal cytotoxicity during murine pregnancy. In: Toder V, Beer AE (eds) Contributions to Gynecology and Obstetrics. Karger, Basel, pp 54–65
Chaouat C, Kolb JP, Chaffaux S, Riviere M, Lankar D, Athanassakis I, Green D, Wegmann TG (1987) The placenta and the survival of the fetal allograft. In: Gill TJ III, Wegmann TG, Nisbet-Brown E (eds) Immunoregulation and fetal survival, Oxford University Press, New York Oxford, pp 231–251
Chaouat G, Clark DA, Wegmann TG (1988) Genetic aspects of the CBA×DBA/2 and B10×B10. A model of murine pregnancy failure and its prevention by lymphocyte immunisation. In: Beard RW, Sharp F (eds) Early pregnancy loss. Springer, London Berlin Heidelberg, pp 89–102
Clark DA, Slapsys RM (1985) Immunregulatory mechanisms in the uterus and survival of the fetus. In: Beer AF, Toder V (eds) Contributions to Gynecology and Obstetrics, vol 14. Karger, Basel, pp 44–53
Clark DA, McDermott M, Sczewzuk MR (1980) Impairment of host vs graft reaction in pregnant mice. II. Selective suppression of cytotoxic cell generation correlates with soluble suppressor activity and with successful allogeneic pregnancy. Cell Immunol 52:106–118
Clark DA, Slapsys RM, Croy BA, Rossant J (1984) Immunoregulation of host versus graft responses in the uterus. Immunol Today 5:111
Delfraissy JF, Tchernia G, Laurian Y (1985) Suppressor cell function after intravenous gammaglobulin treatment in adult chronic idiopathic thrombocytopenic purpura. Br J Haematol 60:315–322
Heine O, Neppert J, Mueller-Eckhardt J (1989) Influence of immunization with allogeneic spleen cells on the number of viable neonates in mice. J Reprod Immunol 15:169–173
Kimberley RP, Salmon JE, Bussell JB (1987) Modulation of mononuclear phagocyte function by intravenous gammaglobulin. J Immunol 132:745–750
Mueller-Eckhardt G, Heine O (1990) Prävention habitueller Aborte mit intravenös verabreichten polyvalenten Immunglobulinen. Gynäkologe 23:160–163
Mueller-Eckhardt G, Heine O, Neppert J, Künzel W, Mueller-Eckhardt C (1989) Prevention of recurrent spontaneous abortion by intravenous immunoglobulin. Vox Sang 56:151–154
Newland AC (1989) Annotation. The use and mechanisms of action of intravenous immunoglobulin: an update. Br J Haematology 72:301–305
Nicholas NS, Panayi GS, Murphy J (1986) Human retroplacental sera inhibit the expression of class II major histocompatibility antigens. J Reprod Immunol 9:95–102
Peters AJ, Coulam CB, Mc Intyre J, Faulk WP (1990) The use of intravenous immunoglobulin for the treatment of recurrent spontaneous abortion. Am J Reprod Immunology 22 (3/4):78
Voisin GA, Chaouat G (1974) Demonstration, nature and properties of maternal antibodies fixed on placenta and directed against paternal antigens. J Reprod Fertil [Suppl] 21:89–96
Wapner RJ, Cowchock FS, Shapiro SS (1989) Successful treatment in two women with antiphospholipid antibodies and refractory pregnancy losses with intravenous immunoglobulin globulin infusions. Am J Obstet Gynecol 161:1271–1272
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heine, O., Mueller-Eckhardt, G., Stitz, L. et al. Influence of treatment with mouse immunoglobulin on the rate of viable neonates in the CBA/J×DBA/2 J model. Res. Exp. Med. 192, 49–52 (1992). https://doi.org/10.1007/BF02576257
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02576257