Abstract
Background
Mucoepidermoid carcinoma (MEC) can have a variety of clinical outcomes, but prognosis seems to be related to the tumor grade. The system proposed by Auclair and Goode is useful, and our data lend further support to its application and validity in clinical practice.
Methods
We have clinicopathologically reviewed 108 cases of MEC originating in major (MASG) and minor (MISG) salivary glands that were treated at the National Cancer Institute of Milan between 1975 and 1995. Following the methods of Auclair and Goode, a quantitative grading system was used. The relationships between clinical and pathologic characteristics and survival rate were investigated.
Results
Twenty-six (44%) cases located in MASG and 19 (39%) cases in MISG were categorized as high-grade tumors. In patients with MASG tumors, the 5-year disease-free survival rate was 22.5% when the tumor was high grade and 97.0% if the tumor was low grade (P<.0001). For patients with a tumor of the MISG, the percentages were 35.3% for high-grade and 80.0% for low-grade tumors (P=.0066).
Conclusions
Our study confirms that in MEC, tumor grade, subdividing cases into low and high grade by using the criteria delineated by Auclair and Goode, correlates well with prognosis.
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References
Spitz MR, Batsakis JG. Major salivary gland carcinoma. Descriptive epidemiology and survival of 498 patients.Arch Otolaryngol 1984; 110: 45–8.
Spiro RH, Huvos AG, Berk R, Strong EW. Mucoepidermoid carcinoma of salivary gland origin: a clinico-pathologic study of 367 cases.Am J Surg 1978; 136: 461–8.
Eveson JW, Cawson RA. A review of 2410 cases with particular reference to histological types, site age and sex distribution.J Pathol 1985; 146: 51–8.
Thordvalsson SE, Beahrs OH, Woolner LB, Simons JN. Mucoepi-dermoid tumors of the major salivary glands.Am J Surg 1978; 120: 432–8.
Nascimento AG, Amaral LP, Prado LA, Kligerman J, Silveira TR. Mucoepidermoid carcinoma of salivary glands: a clinico-pathologic study of 46 cases.Head Neck Surg 1986; 8: 409–17.
Evans HL. Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading.Am J Clin Pathol 1984; 81: 696–701.
Suzuki M, Ichimya I, Matsushita F, Mogi G. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland.J Laryngol Otol 1998; 112: 944–7.
Skalova A, Lehtonen H, von Boguslawsky K, Leivo I. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections.Hum Pathol 1994; 25: 929–35.
Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases.Cancer 1992; 69: 2021–30.
Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands. Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria.Cancer 1998; 82: 1217–24.
Seifert G.Histological Typing of Salivary Gland Tumours. 2nd ed. Berlin: Springer Verlag, 1991.
Sobin LH, Wittekind CH.International Union Against Cancer (UICC). TNM Classification of Malignant Tumours. 5th ed. New York: Wiley, 1997.
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations.J Am Stat Assoc 1958; 53: 457–81.
Clode AL, Fonseca I, Santos JR, Soare J. Mucoepidermoid carcinoma of salivary glands:a reappraisal of the influence of tumor differentiation on prognosis.J Surg Oncol 1991; 46: 100–6.
Hicks MJ, El-Naggar AK, Byers RM, Flaitz M, Luna MA, Batsakis JG. Prognostic factors in mucoepidermoid carcinomas of major salivary glands: a clinicopathologic and flow cytometric study.Eur J Cancer B Oral Oncol 1994; 30B: 329–34.
Plambeck K, Friedrich RE, Hellner D, Donath K, Schmelzle R. Mucoepidermoid carcinoma of salivary gland: clinical data and follow-up in 52 patients.J Cancer Res Clin Oncol 1996; 122: 177–80.
Hamper K, Schimmelpenning H, Caselitz J et al. Mucoepidermoid tumors of salivary glands. Correlation of cytophotometrical data and prognosis.Cancer 1989; 63: 708–17.
Hosokawa Y, Shirato H, Kagei K, et al. Role of radiotherapy for mucoepidermoid carcinoma of salivary gland.Oral Oncol 1999; 35: 105–11.
Jacobsson PA, Blanck C, Eneroth CM. Mucoepidermoid carcinoma of the parotid gland.Cancer 1968; 22: 111–24.
Olsen KD, Devine KD, Weiland LH. Mucoepidermoid carcinoma of the oral cavity.Otolaryngol Head Neck Surg 1981; 89: 783–91.
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Guzzo, M., Andreola, S., Sirizzotti, G. et al. Mucoepidermoid carcinoma of the salivary glands: Clinicopathologic review of 108 patients treated at the National Cancer Institute of Milan. Annals of Surgical Oncology 9, 688–695 (2002). https://doi.org/10.1007/BF02574486
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DOI: https://doi.org/10.1007/BF02574486