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Absence of irradiation induced ischaemic temporal lobe damage in patients with pituitary tumours

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Summary

This study was undertaken to confirm the belief that modern day external beam radiotherapy for patients with pituitary tumours should not be associated with any ischaemic temporal lobe damage. Using the oxygen-15 steady state inhalation technique and positron emission tomography regional temporal lobe blood flow, oxygen extraction fraction and oxygen utilisation were measured in 10 normal volunteers and 11 patients with pituitary tumours treated by irradiation. The patients were studied between 1 and 10.9 years after radiotherapy. We found that temporal lobe oxygen utilisation in the irradiated group (mean 2.11±0.23 ml of O2/100 ml tissue/min) did not differ from the normal group (mean 2.13±0.26 ml of O2/100 ml tissue/min). This suggests that total doses of between 35 and 56 Gy, delivered in fractions of less than 2 Gy, can be given to a pituitary tumour without demonstrable damage to normal temporal lobe.

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References

  1. Frackowiak RJS, Lenzi G-L, Jones T, Heather JD: Quantitative measurements of regional cerebral blood flow and oxygen metabolism in man using15O and positron emission tomography: Theory, procedure and normal values. J Comput Assist Tomogr 4(6):727–736, 1980

    Article  PubMed  CAS  Google Scholar 

  2. Lammertsma AA, Jones T: Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metabol 3:416–424, 1983

    CAS  Google Scholar 

  3. Lammertsma AA, Wise RJS, Heather JD, Gibbs JM, Leender KL, Frackowiak RSJ, Rhodes CG, Jones T: Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients. J Cereb Blood Flow Metabol 3:425–431, 1983

    CAS  Google Scholar 

  4. Williams CW, Crabtree MC, Burgiss SG: Design and performance characteristics of a positron emission computed axial tomograph ECAT-II. IEEE Trans Nucl Sci NS-26:619–627, 1979

    Article  Google Scholar 

  5. Béclère A: The radiotherapeutic treatment of tumours of the hypophysis, gigantism and acromegaly. Arch Roentgenol Radiol 14:147–150, 1909

    Google Scholar 

  6. Henderson WR: The pituitary adenomata. A follow-up study of the surgical results in 338 cases (Dr Harvey Cushing's series). Brit J Surg 26:811–921, 1939

    Article  Google Scholar 

  7. Crompton MR, Layton DD: Delayed radionecrosis of the brain following therapeutic X-radiation of the pituitary. Brain 84:85–101, 1961

    Article  PubMed  CAS  Google Scholar 

  8. Peck Jr FC, McGovern ER: Radiation necrosis of the brain in acromegaly. J Neurosurg 25:536–542, 1966

    Article  PubMed  Google Scholar 

  9. Almquist S, Dahlgren S, Notter G, Sundbom L: Brain necrosis after irradiation of the hypophysis in Cushing's disease. Acta Radiol (Diagn) (Stockh) 2:179–188, 1964

    CAS  Google Scholar 

  10. Kramer S: Brain necrosis after irradiation of pituitary tumours and craniopharyngiomas. Clin Neurosurg 15:301–18, 1968

    PubMed  CAS  Google Scholar 

  11. Rubin P, Casarett GW: Clinical Radiation Pathology. In: Rubin P, Casarett GW (eds) WB Saunders, Philadelphia, Chapter 16, 1968

    Google Scholar 

  12. Atkinson AB, Allen IV, Gordon DS, Hadden DR, Maguire CJF, Trimble ER, Lyons AR: Progressive visual failure in acromegaly following external pituitary irradiation. Clin Endocrinol 10:469–479, 1979

    CAS  Google Scholar 

  13. Sheline GE, Wara WM, Smith V: Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6:1215–1228, 1980

    PubMed  CAS  Google Scholar 

  14. Coulter C: Principles of pituitary irradiation. In: Belchetz PE (ed) Management of Pituitary Disease. Chapman and Hall, London, 1984, pp 293–305

    Google Scholar 

  15. Aristizabel S, Caldwell WL, Arila J: The relationship of time-dose fractionation factors to complications in the treatment of pituitary tumours by irradiation. Int J Radiat Oncol Biol Phys 2:667–673, 1977

    Google Scholar 

  16. Feek CM, McLelland J, Seth J, Toft AD, Irvine WJ, Padfield PL, Edwards CRW: How effective is external pituitary irradiation for growth hormone-secreting pituitary tumours? Clin Endocrinol 20:401–408, 1984

    CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W 12 OHS, London, UK

    R. P. Beaney, D. J. Brooks & T. Jones

  2. Dept of Medicine (Endocrine Unit), Hammersmith Hospital, Du Cane Road, W 12 OHS, London, UK

    J. S. R. Gibbs & G. F. Joplin

  3. Dept of Radiotherapy and Oncology, Hammersmith Hospital, Du Cane Road, W 12 OHS, London, UK

    C. G. McKenzie

Authors
  1. R. P. Beaney
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  2. J. S. R. Gibbs
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  3. D. J. Brooks
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  4. C. G. McKenzie
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  5. G. F. Joplin
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  6. T. Jones
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Beaney, R.P., Gibbs, J.S.R., Brooks, D.J. et al. Absence of irradiation induced ischaemic temporal lobe damage in patients with pituitary tumours. J Neuro-Oncol 5, 129–137 (1987). https://doi.org/10.1007/BF02571301

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  • DOI: https://doi.org/10.1007/BF02571301

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