Abstract
In vitro incubation of human erythrocytes and platelets with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin in the concentration range 1 nM to 10μM did not affect the activity of the Na+−K+-pump, Na+−K+-cotransport or Na+−Li+-countertransport, or the ground membrane leak for Na+ and K+.
The data indicate that pravastatin has no direct effect on transmembrane cationic transport systems in red blood cells or platelets.
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Lijnen, P., Petrov, V. & Amery, A. Pravastatin has no direct effect on transmembrane cationic transport systems in human erythrocytes and platelets. Eur J Clin Pharmacol 47, 281–283 (1994). https://doi.org/10.1007/BF02570509
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DOI: https://doi.org/10.1007/BF02570509