Abstract
The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At −50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.
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Kimitsuki, T., Nakagawa, T., Hisashi, K. et al. The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells. Eur Arch Otorhinolaryngol 251 (Suppl 1), S53–S56 (1994). https://doi.org/10.1007/BF02565220
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DOI: https://doi.org/10.1007/BF02565220