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Profiles of resting potentials across the stria vascularis in kanamycin-deafened guinea pigs

  • Inner Ear
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Abstract

The resting potentials of the marginal cells in the stria vascularis of the guinea pig were determined from changes in the combined electrode-tissue resistance of the electrode. The resistance of the electrode was 45.5±16.0 MΩ (n=20) before penetration of the stria vascularis and 46.7±17.3 MΩ (n=20) after penetration. The resistance drops across the luminal membrane of the marginal cells were 46.0±22.6 MΩ (n=12) in kanamycin-deafened guineal pigs and 54.5±33.1 MΩ (n=9) in normal guinea pigs. The endocochlear potential (EP) and resting potentials in the marginal cells were 90.1±6.0 mV (n=14) and 70.4±11.3 mV (n=14) in kanamycin-deafened guinea pigs and 84.8±5.1 mV (n=29) and 74.7±11.7 mV (n=29) in normal guinea pigs. The resting potentials in the marginal cells decreased gradually and were approximately 0 mV around 20 min after anoxia in both kanamycin-deafened and normal guinea pigs. These changes were comparable to those of EP in kanamycin-deafened guinea pigs during anoxia. The mechanism of the EP in kanamycin-deafened guinea pigs is discussed.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan

    S. Komune, H. Inoue, S. Wakizono, T. Nakagawa, T. Kimitsuki & T. Uemura

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  1. S. Komune
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  2. H. Inoue
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  3. S. Wakizono
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  4. T. Nakagawa
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  6. T. Uemura
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Komune, S., Inoue, H., Wakizono, S. et al. Profiles of resting potentials across the stria vascularis in kanamycin-deafened guinea pigs. Eur Arch Otorhinolaryngol 251 (Suppl 1), S43–S47 (1994). https://doi.org/10.1007/BF02565218

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  • DOI: https://doi.org/10.1007/BF02565218

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