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Nitric oxide donor, linsidomine chlorhydrate (SIN-1), in the diagnosis and treatment of erectile dysfunction: Critical appraisal and review of the literature

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Abstract

Recent experimental work has demonstrated that nitric oxide (NO) is the neutrotransmitter responsible for cavernous smooth muscle relaxation. Different studies on the performance of the direct NO-donor linsidomine chlorhydrate (SIN-1) in patients with erectile dysfunction have come to conflicting results ranging from highest praise to complete dismissal. We reviewed all published studies on the use of SIN-1 for intracorporeal injection in erectile failure including our own. To this date, 3 groups published their data. Only the uncontrolled data from Hannover claim good results. The controlled data from Hamburg and Berlin on patients with erectile failure due to venous leakage, to a mixed aetiology in a double-blind fashion and to mixed aetiology with drug increase (1 mg versus 2 mg of SIN-1) showed a significantly worse performance of SIN-1 compared to the standard drug for penile injection, prostaglandin E1. We conclude that there is no place for linsidomine chlorhydrate in either the diagnosis or the treatment of erectile dysfunction.

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Authors and Affiliations

  1. Department of Urology, Benjamin Franklin Medical Center, Free University, Berlin, Germany

    H. E. H. Wegner, H. H. Knispel, T. Meier, R. Klän & K. Miller

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  1. H. E. H. Wegner
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  2. H. H. Knispel
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  3. T. Meier
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  4. R. Klän
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  5. K. Miller
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Wegner, H.E.H., Knispel, H.H., Meier, T. et al. Nitric oxide donor, linsidomine chlorhydrate (SIN-1), in the diagnosis and treatment of erectile dysfunction: Critical appraisal and review of the literature. International Urology and Nephrology 27, 621–628 (1995). https://doi.org/10.1007/BF02564750

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