Abstract
Hormonal and ultrastructural examinations of the testis were performed in a patient with Down's syndrome. Plasma testosterone was abnormally low, and circulating levels of LH and FSH were higher than the normal range. The administration of HCG resulted in a low response of plasma testosterone. Electron microscopy revealed proliferation of smooth endoplasmic reticulum, an increase in paracry stalline inclusions and the absence of Reinke's crystals in Leydig cells.
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Sasagawa, I., Nakada, T., Kubota, Y. et al. Ultrastructure of Leydig cells in Down's syndrome. International Urology and Nephrology 27, 587–591 (1995). https://doi.org/10.1007/BF02564745
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DOI: https://doi.org/10.1007/BF02564745